{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:14Z","timestamp":1787014334969,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Novel biologics targeting the IL23\/T\u201017 axis, such as tildrakizumab, have been developed to treat psoriasis. There is limited evidence on the use of tildrakizumab for the treatment of psoriasis in difficult\u2010to\u2010treat areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our aim was to evaluate the short\u2010term efficacy and safety of tildrakizumab in patients with moderate\u2010to\u2010severe psoriasis and with the involvement of difficult\u2010to\u2010treat areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicentric retrospective study was conducted on patients who initiated tildrakizumab between July 2022 and July 2023. Psoriasis Area and Severity Index (PASI), Psoriasis Scalp Severity Index (PSSI), Palmoplantar Psoriasis Area and Severity Index (ppPASI), and Nail Psoriasis Severity Index (NAPSI) were measured at baseline and after 16\u2009weeks. The percentages of achieving a PASI75, PASI90, or PASI100 response were assessed. Dermatology Life Quality Index (DLQI) and Itch Visual Analog Scale (VAS) were measured simultaneously. Data about potential safety issues and adverse events were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 76 patients were included, and 59 (77.6%) were affected by psoriasis localized to the scalp (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932), palmoplantar locations (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913), or nails (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914). The mean PASI score decreased from 16.5\u2009\u00b1\u20099.8 at baseline to 1.9\u2009\u00b1\u20091.6 after 16\u2009weeks. Tildrakizumab treatment resulted in the improvement of PSSI (19.9\u2009\u00b1\u200910.7 to 2.7\u2009\u00b1\u20094.2), ppPASI (15.4\u2009\u00b1\u20096.9 to 1.9\u2009\u00b1\u20092.3), and NAPSI (20.3\u2009\u00b1\u200916.9 to 7.6\u2009\u00b1\u200910.8) from baseline to 16\u2009weeks, respectively. DLQI and Itch VAS also showed marked improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tildrakizumab is a valuable option for treating difficult\u2010to\u2010treat psoriasis and pruritus, with rapid onset of action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.17368","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T23:54:18Z","timestamp":1720828458000},"page":"319-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Short\u2010term efficacy of tildrakizumab on difficult\u2010to\u2010treat areas: a real\u2010world experience"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-216X","authenticated-orcid":false,"given":"Sara","family":"Cacciapuoti","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-0592","authenticated-orcid":false,"given":"Luca","family":"Potestio","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Gallo","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Musumeci","sequence":"additional","affiliation":[{"name":"UOC Dermatologia, PO G. Rosolico AOU Policlinico \"G. Rodolico\u2010San Marco\"  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-9232","authenticated-orcid":false,"given":"Giacomo","family":"Caldarola","sequence":"additional","affiliation":[{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli \u2013 IRCCS  Rome Italy"},{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"D'Amico","sequence":"additional","affiliation":[{"name":"UOC Dermatologia, AOU \"R.\u00a0Dulbecco\" Ospedale 'A. Pugliese'  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Caudullo","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Papaianni","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"De Simone","sequence":"additional","affiliation":[{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli \u2013 IRCCS  Rome Italy"},{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketty","family":"Peris","sequence":"additional","affiliation":[{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. 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