{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:35:18Z","timestamp":1788014118653,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hematopoietic stem cell transplantation (HSCT) has improved outcomes for severe hematologic, malignant, and immune disorders, yet poses an increased risk of subsequent malignancies. This study aimed to examine the risk of skin cancer following HSCT and identify potential risk factors. The search was conducted in MEDLINE, EMBASE, and CINAHL databases until December 2023. Cohort studies reporting standardized incidence ratios (SIRs) for post\u2010HSCT skin cancer or investigating risk factors were included. SIRs, or hazard ratios (HRs) with 95% confidence interval (CI), were calculated using random\u2010effects inverse\u2010variance models. Outcome endpoints were SIRs of skin cancer post\u2010HSCT and risk factors, including gender, chronic graft\u2010versus\u2010host disease (cGVHD), voriconazole exposure, and total body irradiation (TBI). Twenty\u2010six studies involving 164,944 HSCT recipients (allogeneic HSCT,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200968,637; autologous HSCT,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200995,435; mean age: 38.5\u2009\u00b1\u200913.8\u2009years; 71,354 females [43.3%]) were analyzed. Overall, SIR for skin cancer post\u2010HSCT was 7.21 (95% CI 3.98\u201313.08), with SIRs of 2.25 (95% CI: 1.37\u20133.68) for autologous HSCT, and 10.18 (95% CI 5.07\u201320.43) for allogeneic HSCT. Risk factors for skin cancer risk included cGVHD (HR\u2009=\u20092.86 [95% CI: 2.01\u20134.07]), specifically for basal cell and squamous cell carcinoma (SCC) (HR\u2009=\u20091.80 [95% CI: 1.31\u20132.46] and HR\u2009=\u20093.68 [95% CI: 2.39\u20135.68], respectively), male gender (HR\u2009=\u20091.56 [95% CI: 1.15\u20132.13]), especially for SCC (HR\u2009=\u20091.70 [95% CI: 1.03\u20132.80]), and voriconazole exposure (HR\u2009=\u20092.01 [95% CI: 1.12\u20133.61]). TBI showed no statistically significant association with subsequent skin cancer (HR\u2009=\u20091.12 [95% CI: 0.73\u20131.71]). These findings highlight the importance of rigorous skin cancer surveillance and preventive strategies in HSCT recipients, particularly in male individuals undergoing allogeneic transplants and those with identifiable risk factors, to enable early detection and intervention.\n                  <\/jats:p>","DOI":"10.1111\/ijd.17371","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T23:49:01Z","timestamp":1720655341000},"page":"1691-1700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Skin cancer risk after hematopoietic stem cell transplantation: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-6723","authenticated-orcid":false,"given":"Miguel","family":"Mansilla\u2010Polo","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario y Polit\u00e9cnico La Fe  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