{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:47:08Z","timestamp":1790938028876,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenetic alopecia (AGA) is a prevalent hair loss disorder with psychological repercussions. Traditional treatments have limitations, leading to the exploration of regenerative therapies such as exosomes derived from adipose tissue stem cells (ASC\u2010Exosomes).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>First, using human hair follicle (HF) dermal papilla cells (hDPCs) treated with ASC\u2010Exosomes, ALP, VCAN, \u03b2\u2010catenin, and LEF\u20101 levels with RT\u2010PCR and p\u2010GSK3\u03b2, GSK3\u03b2, \u03b2\u2010catenin, ALP, and \u03b2\u2010actin levels with western blot analysis were assessed. Hair shaft elongation test and assay for ALP, Ki\u201067, and \u03b2\u2010catenin were done using human HF organ culture. Patients with AGA had ASC\u2010Exosomes treatment and were evaluated for hair counts, photographic assessments, subjective satisfaction, and safety profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ASC\u2010Exosomes impact hDPCs, increasing proliferation and the upregulation of hair growth\u2010related genes, including ALP, VCAN, \u03b2\u2010catenin, and LEF\u20101. The Wnt\/\u03b2\u2010catenin pathway was activated, indicating their role in promoting hair growth. ASC\u2010Exosomes also promoted hair shaft elongation and ALP activity, suggesting a potential for hair regeneration. Thirty participants with AGA enrolled and treated over 24\u2009weeks. The subjects experienced a significant increase in total hair density, improved global photographic assessments, and reported higher subjective satisfaction without severe adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This research contributes to the growing body of evidence supporting the use of exosomes in hair loss treatment, offering a safe and effective alternative for individuals with AGA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.17406","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T01:30:23Z","timestamp":1724031023000},"page":"1212-1220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The efficacy of adipose stem cell\u2010derived exosomes in hair regeneration based on a preclinical and clinical study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9066-3662","authenticated-orcid":false,"given":"Ester","family":"Lee","sequence":"first","affiliation":[{"name":"ExoCoBio Exosome Institute (EEI) ExoCoBio Inc.  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Hoon","family":"Kwon","sequence":"additional","affiliation":[{"name":"Oaro Dermatology Institute  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"Dod Dermatologic Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5449-8313","authenticated-orcid":false,"given":"Byung Cheol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Dankook University  Cheonan Republic of Korea"},{"name":"Dermatologic Translational Research Institute  Cheonan Republic of 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