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This narrative review aims to identify appropriate treatments to facilitate a holistic management approach to acne (One Acne\u2122), sensitive skin, and acne\u2010induced sequelae and describe the role of treatments in improving skin quality. Topical retinoids are considered the preferred first\u2010line option for acne treatment by dermatologists, either as monotherapy or in combination with other treatments, because of their ability to target various aspects of the disease. Tretinoin, trifarotene, adapalene, and tazarotene have all been assessed in clinical studies for managing acne\u2010associated scarring, with varying success, with the latter three reported to improve skin quality. Moreover, some corrective procedures, e.g., injectable non\u2010animal stabilized hyaluronic acid (NASHA) fillers, have proven effective for treating acne scarring. Both treatment types may complement each other to provide optimal treatment outcomes and patient satisfaction, as observed in several patients receiving concomitant treatment with NASHA fillers\/topical trifarotene. Adjunctive use of cleansers, moisturizers, and photoprotection\u2010containing ingredients such as vitamin B3, glycerin, or pro\u2010vitamin B3 may also complement drug\/corrective treatments to reduce skin irritation and risk of scarring, as well as improve skin hydration, tone, and overall appearance. This narrative review highlights that comprehensive skincare regimens should be used throughout acne patients' journeys to reduce treatment\u2010related irritation, improve treatment outcomes, adherence, and satisfaction, and enhance overall skin quality. Patients with sensitive skin should choose tailored skincare products to maintain skin barrier integrity and restore skin function.<\/jats:p>","DOI":"10.1111\/ijd.17546","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:08:41Z","timestamp":1731888521000},"page":"637-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["One Acne\u2122: A holistic management approach to improve overall skin quality and treatment outcomes in acne with or without sensitive skin"],"prefix":"10.1111","volume":"64","author":[{"given":"Leon","family":"Kircik","sequence":"first","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Tan","sequence":"additional","affiliation":[{"name":"University of Western Ontario  Windsor ON Canada"},{"name":"Windsor Clinical Research Inc  Windsor ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward (Ted)","family":"Lain","sequence":"additional","affiliation":[{"name":"Sanova Dermatology  Austin TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Beleznay","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia  Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-1563","authenticated-orcid":false,"given":"Rajeev","family":"Chavda","sequence":"additional","affiliation":[{"name":"Galderma SA  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nad\u00e8ge","family":"Lachmann","sequence":"additional","affiliation":[{"name":"Galderma SA  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjinta","family":"Brinkhuizen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Catharina Hospital Eindhoven Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson Medical Center  New Brunswick NJ USA"},{"name":"The Acne Treatment and Research Center  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Layton","sequence":"additional","affiliation":[{"name":"Skin Research Centre University of York  York UK"},{"name":"Department of Dermatology Harrogate and District NHS Trust  Harrogate UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19349"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_2_7_4_1","unstructured":"Galderma.Acne's hidden truth: burden summary report; combined facial and truncal acne 2020. 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