{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:00:59Z","timestamp":1790766059688,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary cutaneous B\u2010cell lymphomas (PCBCLs) are rare cutaneous neoplasms with limited literature regarding treatment options and associated treatment outcomes. This study aimed to investigate and present real\u2010world treatment outcomes in patients with PCBCLs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with PCBCL who were treated in five major referral centers for cutaneous lymphoma in Greece over 10\u2009years were retrospectively included with their baseline characteristics and treatment\u2010associated outcomes collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 235 PCBCL patients, of whom 125 (53.2%) were females, were included. The median age at diagnosis was 60\u2009years (IQR 47\u201372), and the median follow\u2010up duration was 3\u2009years (IQR 1.3\u20136.4). The most common subtype was primary cutaneous marginal zone lymphoma (PCMZL) (52.3%), followed by primary cutaneous follicle center lymphoma (PCFCL) (40.9%), and primary cutaneous large B\u2010cell lymphoma, leg type (PCDLBCL, LT) with 16 (6.8%) cases. Complete responses (CRs) were observed in 77.3% after first\u2010line treatment. Both radiotherapy (RT) and surgical excision (SE) achieved superior outcomes, with 88.9% and 89% achieving CR, respectively. Relapses occurred in 22.6% of initial complete responders. The median time to the next treatment (TTNT) for the PCMZL and PCFCL was 349\u2009days. RT and topical\/intralesional steroids demonstrated longer TTNT compared to SE (445 and 359 vs. 154\u2009days). For PCMZL and PCFCL, the 1\u2010year progression\u2010free survival (PFS) was 84.2% (75.7\u201389.9) and 85% (75.1\u201391.2), and the 5\u2010year PFS was 66.5% (55.2\u201375.5) and 58.8% (44.4\u201370.7), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PCBCLs have favorable outcomes. RT demonstrates significantly increased TTNT compared to SE, suggesting RT as the preferable option. After careful evaluation, \u201cwatch and wait\u201d may be a reasonable option for asymptomatic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17564","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T12:09:03Z","timestamp":1731326943000},"page":"882-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical features, treatment options and outcomes in primary cutaneous B\u2010cell lymphomas: a real\u2010world, multicenter, retrospective study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9152","authenticated-orcid":false,"given":"Vasiliki","family":"Nikolaou","sequence":"first","affiliation":[{"name":"First Department of Dermatology, \u201cAndreas Sygros\u201d Hospital for Skin Diseases National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1156-7139","authenticated-orcid":false,"given":"Ioannis\u2010Alexios","family":"Koumprentziotis","sequence":"additional","affiliation":[{"name":"First Department of Dermatology, \u201cAndreas Sygros\u201d Hospital for Skin Diseases National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Papadavid","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology, \u201cAttikon\u201d General Hospital National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Patsatsi","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinic, Second Dermatology Department Aristotle University School of Medicine, Papageorgiou General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavrianna","family":"Diavati","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, Laikon General Hospital National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-0762","authenticated-orcid":false,"given":"Antonios","family":"Tsimpidakis","sequence":"additional","affiliation":[{"name":"First Department of Dermatology, \u201cAndreas Sygros\u201d Hospital for Skin Diseases National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Kruger\u2010Krasagakis","sequence":"additional","affiliation":[{"name":"Department of Dermatology University General Hospital of Heraklion  Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Doxastaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology University General Hospital of Heraklion  Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Marinos","sequence":"additional","affiliation":[{"name":"Hemopathology Department \u201cEvangelismos\u201d General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Kaliampou","sequence":"additional","affiliation":[{"name":"First Department of Dermatology, \u201cAndreas Sygros\u201d Hospital for Skin Diseases National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gerochristou","sequence":"additional","affiliation":[{"name":"First Department of Dermatology, \u201cAndreas Sygros\u201d Hospital for Skin Diseases National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Koumourtzis","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology, \u201cAttikon\u201d General Hospital National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0421-9424","authenticated-orcid":false,"given":"Vasiliki","family":"Pappa","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine and Research Unit University General Hospital \u201cAttikon\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrosini","family":"Kypraiou","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology, \u201cAttikon\u201d General Hospital National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Kouloulias","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology, \u201cAttikon\u201d General Hospital National &amp; 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