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This review discusses clinical studies examining co\u2010management strategies and identifies current practice gaps. Dermatology Life Quality Index scores are higher in individuals with vitiligo or melasma. It is plausible that populations experiencing both conditions may exhibit worsened psychological outcomes because of stigmas and perceived social beauty standards. Standard treatments for vitiligo aim to increase pigmentation, while AHD treatments target decreasing pigmentation, causing potential worsening of contrast between multiple skin tones for patients experiencing both disorders. Tretinoin may prevent narrowband ultraviolet B (NBUVB)\u2010induced hyperpigmentation in patients with vitiligo without altering treatment response and is also beneficial for managing AHD. In addition, the use of oral tranexamic acid to treat melasma does not diminish the response to NBUVB phototherapy. Platelet\u2010rich plasma (PRP) injections and oral <jats:italic>Polypodium leucotomos<\/jats:italic> extract may also be beneficial for comanaging vitiligo and AHD. However, practice guidelines are needed to optimize care for this patient population.<\/jats:p>","DOI":"10.1111\/ijd.17631","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T09:47:08Z","timestamp":1737020828000},"page":"485-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Concurrent management of vitiligo and acquired disorders of hyperpigmentation: a comprehensive literature review and current practice gaps"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-9114","authenticated-orcid":false,"given":"Brittany N.","family":"Lane","sequence":"first","affiliation":[{"name":"Henry Ford Jackson Hospital  Jackson MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iltefat H.","family":"Hamzavi","sequence":"additional","affiliation":[{"name":"Division of Photobiology and Photomedicine, Department of Dermatology Henry Ford 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