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In recent decades, the Janus kinase\u2010signal transducers and activators of transcription (JAK\u2013STAT) pathway have been implicated in the pathogenesis of various skin diseases, including GA. This pathway involves T\u2010helpers and macrophages, launching a cytokine cascade that plays a crucial role in the disease pathology. Janus kinase (JAK) inhibitors can prevent cytokine involvement. To date, limited clinical data has been reported about the effectiveness of JAK inhibitors on granulomatous diseases. This review aims to examine studies that have reported off\u2010label use of different JAK inhibitors in treating GA, focusing on their effectiveness and safety. Since there is no definitive treatment for GA, evaluating the role of JAK inhibitors could help establish a consensus on their future use in this type of medication.<\/jats:p>","DOI":"10.1111\/ijd.17684","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T01:51:35Z","timestamp":1739238695000},"page":"1371-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Emerging Role of Janus Kinase Inhibitors in Treating Granuloma Annulare: A Clinical, Narrative Review of Efficacy and Safety"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2683-3750","authenticated-orcid":false,"given":"Sama","family":"Heidari","sequence":"first","affiliation":[{"name":"Department of Dermatology Razi Hospital, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-5670","authenticated-orcid":false,"given":"Reza","family":"Omid","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5223-5391","authenticated-orcid":false,"given":"Hanie","family":"Babaie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-1458","authenticated-orcid":false,"given":"Zeinab","family":"Aryanian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,9]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"5","article-title":"Janus Kinase Inhibitors: A Review of Their Emerging Applications in Dermatology","volume":"23","author":"Cinats A.","year":"2018","journal-title":"Skin Therapy Letter"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00726-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2023.03.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14051001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054624"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010021\u201000636\u20101"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.05.098"},{"key":"e_1_2_7_9_1","unstructured":"E.Hwang \u201cJanus Kinase Inhibition In Granuloma Annulare: Two Single\u2010Arm Open\u2010Label Clinical Trials \u201d2024."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010024\u201001117\u2010z"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.206119"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X211039477"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13875"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2019.10.016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.07.054"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1360"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_215_2024"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15641"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18031"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19073"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llac110"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/jcia.2024.13892"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15211"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2023.01.027"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2023.11.024"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8859178"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.70092"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5070\/D330564430"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2024.2313090"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15426"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.05.030"},{"key":"e_1_2_7_33_1","first-page":"91","article-title":"Ringed Eruption on the Fingers","volume":"7","author":"Fox T. 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