{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:59:02Z","timestamp":1755223142584,"version":"3.43.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Haptoglobin (Hp) is an acute\u2010phase protein and an independent marker for hidradenitis suppurativa (HS) severity. The different Hp genotypes (Hp 1\u20131, Hp 1\u20132, and Hp 2\u20132) differ in their antioxidant and anti\u2010inflammatory functions. Hp genotypes have never been investigated in HS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim was to characterize and determine the frequency of Hp genotypes in HS patients. Additionally, the characteristics of the different Hp genotypes are analyzed for differences in personal, disease\u2010specific, and laboratory parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genomic DNA was extracted from peripheral blood leukocytes using the Maxwell RSC Blood DNA Kit. Polymerase chain reaction (PCR) products were separated and analyzed using 0.7% agarose gels for genotyping. The chi\u2010square test, Kruskal\u2013Wallis test, and\/or post hoc analysis with the Dunn\u2013Bonferroni test were used to determine differences between the different genotypes and HS characteristics. We compared the genotype distribution in HS with 69 randomly selected, unmatched, and healthy control patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 72 patients with HS were included in this study, including 29 women (40.3%) and 43 men (59.7%). A positive family history of HS was reported by 29.2% of patients (<jats:italic>n<\/jats:italic>\u2009=\u200921). Hp genotype 1\u20131 was present in 20.8%, Hp 1\u20132 in 33.3%, and Hp 2\u20132 in 45.8% of HS patients. The control group had a similar Hp distribution with 18.8%, 37.7%, and 43.5%, respectively. A positive family history of HS was significantly more frequent in Hp 2\u20132 (42.4%) compared to Hp 1\u20131 (6.7%) and Hp 1\u20132 (25%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.035). The number of HS flares in the last 4\u2009weeks was significantly higher in Hp 2\u20132 patients compared to Hp 1\u20132 patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hp genotype 2\u20132 and the Hp2 allele were significantly more associated with familial HS than the other genotypes. In addition, HS patients with genotypes 2\u20132 had more frequent flare\u2010ups than those with the different genotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17705","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:39:08Z","timestamp":1741757948000},"page":"1227-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Haptoglobin Genotypes in Hidradenitis Suppurativa: Haptoglobin 2\u20132 Genotype Is Associated With Familial Hidradenitis Suppurativa and More Flares"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-0743","authenticated-orcid":false,"given":"Nessr","family":"Abu Rached","sequence":"first","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum Germany"},{"name":"Skin Cancer Center, 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Allergology Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannik","family":"Haven","sequence":"additional","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum Germany"},{"name":"Skin Cancer Center, Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Myszkowski","sequence":"additional","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum Germany"},{"name":"Skin Cancer Center, Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum 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