{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:28:24Z","timestamp":1783358904918,"version":"3.54.6"},"reference-count":64,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014812","name":"Nordic Pharma Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Methotrexate (MTX) is a conventional systemic therapy widely used to treat chronic plaque\u2010type psoriasis, a chronic inflammatory skin disease that significantly impacts patients' quality of life. MTX can be administered orally or subcutaneously. Over the past decades, the use of subcutaneous versus oral MTX has been a subject of ongoing debate among dermatologists. Therefore, this literature review aimed to investigate the differences between oral and subcutaneous MTX described in the scientific literature in terms of intestinal absorption and bioavailability, efficacy, safety, patient satisfaction and quality of life, treatment adherence, and economic outlook. Thirty\u2010two articles were included in the review, notably including evidence\u2010based guidelines on the management of psoriasis, as well as randomized clinical trials and real\u2010world studies. Only European guidelines recommend the use of subcutaneous MTX over oral MTX; hence, the use of subcutaneous MTX is reported almost exclusively in European countries. Despite the paucity and heterogeneity of the literature, findings from the review suggest that subcutaneous MTX may overcome some limitations of the oral route in terms of intestinal absorption, bioavailability, and safety. Moreover, subcutaneous MTX may provide higher efficacy with a faster, or even greater, response in psoriatic patients and better adherence to treatment. In conclusion, subcutaneous MTX tends to be advantageous with regard to psoriasis management, similar to other chronic inflammatory diseases like rheumatoid arthritis; however, this comes with a higher cost. The treatment of psoriasis using subcutaneous MTX deserves further study, especially in the biologics age.<\/jats:p>","DOI":"10.1111\/ijd.17758","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T11:21:01Z","timestamp":1743592861000},"page":"1558-1567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comprehensive Literature Review Evaluating the Use, Safety, and Efficacy of Subcutaneous Methotrexate in the Treatment of Adult Patients With Moderate\u2010To\u2010Severe Plaque\u2010Type Psoriasis"],"prefix":"10.1111","volume":"64","author":[{"given":"Manuelle","family":"Viguier","sequence":"first","affiliation":[{"name":"Department of Dermatology Robert Debr\u00e9 University Hospital  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-0771","authenticated-orcid":false,"given":"Jos\u00e9\u2010Manuel","family":"Carrascosa\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitari Germans Trias i Pujol, IGTP, UAB  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pariyawan","family":"Rakvit","sequence":"additional","affiliation":[{"name":"Dermatology Department East Lancashire Hospitals Trust  Blackburn UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Magdalena","family":"Constantin","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"},{"name":"IInd Department of Dermatology Colentina Clinical Hospital  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-4884","authenticated-orcid":false,"given":"Alice\u2010Ana\u00efs","family":"Varlet","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Public Health Expertise  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solenn","family":"Le Clanche","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Public Health Expertise  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A. W.","family":"Verhagen","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Nordic Pharma  Hoofddorp the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf\u2010Henning","family":"Boehncke","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology Geneva University Hospitals  Geneva Switzerland"},{"name":"Department of Pathology and Immunology University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12495"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.628"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13051"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.044"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1080-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475418814234"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00579"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.058"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.10.013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16424"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090654"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S2740"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1133885"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3593"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0373-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2017.08.012"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153740"},{"key":"e_1_2_8_23_1","volume-title":"StatPearls","author":"Hanoodi M.","year":"2024"},{"key":"e_1_2_8_24_1","first-page":"55","article-title":"Topical Psoriasis Therapies and Unmet Patient Needs: The Importance of Optimizing Methotrexate","volume":"97","author":"Greenberg R.","year":"2016","journal-title":"Cutis"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13656"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19690"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.15102"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2018.11.011"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15628"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16915"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15340"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1578-2190(10)70682-X"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.1410"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806\u20104841.2019940211"},{"key":"e_1_2_8_35_1","unstructured":"National Institute for Health and Care Excellence (NICE) \u201cPsoriasis: Assessment and Management \u201d (2017) https:\/\/www.nice.org.uk\/guidance\/cg153\/resources\/psoriasis\u2010assessment\u2010and\u2010management\u2010pdf\u201035109629621701."},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18698"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.06.382"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80342-8"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01945-6"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12920"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2784\u20108671.21.07132\u20102"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2599"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102130"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2215354"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S311269"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S154745"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205228"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12161"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600780219"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32127-4"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010858"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15656"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.1.107"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15945"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30041"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_157_18"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13409"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0486-7"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0295-8"},{"key":"e_1_2_8_60_1","unstructured":"R.Caporali \u201cExploring Methotrexate Route of Administration Decisions for Adults With Rheumatoid Arthritis \u201d (2023) https:\/\/www.emjreviews.com\/flagship\u2010journal\/article\/exploring\u2010methotrexate\u2010route\u2010of\u2010administration\u2010decisions\u2010for\u2010adults\u2010with\u2010rheumatoid\u2010arthritis\u2010j190423\/."},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10165\u2010008\u20100123\u20103"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969\u2010018\u20100255\u20108"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221085889"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02439-y"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16357"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.17758","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:22:12Z","timestamp":1778246532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.17758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/ijd.17758"],"URL":"https:\/\/doi.org\/10.1111\/ijd.17758","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"2024-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}