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Despite these dangers, several medications derived from snake venom have gained Food and Drug Administration (FDA) approval, marking significant advancements in therapeutic applications. Notably, neurotoxins have garnered attention in pain research due to their demonstrated analgesic and anesthetic properties, offering potential benefits in dermatological disorders associated with pain symptoms. Recent murine studies of snake\u2010derived neurotoxins such as mambalgin\u20101, mambalgin\u20102, crotamine, and cobrotoxin have shown efficacy in alleviating neuropathic and chronic pain, often outperforming traditional analgesics like morphine, with fewer adverse effects reported. Limited applications of these venom components in humans, including local injections for the treatment of neuropathic pain and inflammation, have yielded encouraging findings through observational studies. Beyond pain relief, snake venom's benefits also extend to anti\u2010aging treatments through their paralytic effects, with synthetic neurotoxins now available in various cosmetic products. This review explores the advancements in snake venom\u2010based therapies, focusing on their analgesic, anesthetic, and aesthetic properties in the treatment of dermatological conditions.<\/jats:p>","DOI":"10.1111\/ijd.17760","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T18:03:31Z","timestamp":1743357811000},"page":"1213-1219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Snakes and Skin: A Review of Aesthetic, Analgesic, and Anesthetic Snake Venom Applications"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-3276","authenticated-orcid":false,"given":"Elena E.","family":"Skaribas","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center at Houston John P. And Kathrine G. 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