{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:46:59Z","timestamp":1792511219094,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013226","name":"Les Laboratories Pierre Fabre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Xerosis cutis (dry skin) is a common dermatological condition that occurs when the water\u2010holding or barrier functions of the skin are impaired. In addition to external triggers, xerosis cutis may be caused by endogenous factors (e.g., aging) or present as a symptom of other diseases, such as atopic dermatitis, psoriasis, ichthyosis, and diabetes. Basic emollients restore skin hydration and barrier function through the biophysical properties of their non\u2010active constituents and are routinely recommended for treating xerosis cutis and diseases associated with dry skin. As newer \u201cemollients plus\u201d containing active ingredients become available, we believe there is still a place for basic emollients as safe and cost\u2010effective treatment options for the long\u2010term management of dry skin. The previous article in this supplement reviewed basic emollients for the treatment of xerosis cutis in atopic dermatitis; herein, we review evidence describing the clinical value of basic emollients for dry skin associated with other causes. Twenty\u2010one literature searches were performed to identify clinical studies of basic emollients containing one or more of the following ingredients: almond and coconut oils, amino acids, chondroitin, dexpanthenol, glucose, glycerol, glycosaminoglycans, hyaluronic acid, lactic acid, lanolin, olive oil, paraffin, petrolatum, phospholipids, polyunsaturated fatty acids, pyroglutamic acid, squalene, triglycerides, urea, vegetable oils, and vitamin E. Despite wide variations in study design and outcome measures, articles of interest identified by the authors show that most basic emollient formulations are safe and effective at improving dry skin associated with senile xerosis, uremic xerosis, psoriasis, ichthyosis, and diabetes. Overall, current clinical evidence reaffirms that regular and ongoing emollient use should be the mainstay of basic therapy for xerosis cutis and diseases associated with dry skin.<\/jats:p>","DOI":"10.1111\/ijd.17794","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T11:31:08Z","timestamp":1748604668000},"page":"29-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Basic Emollients for Xerosis Cutis Not Associated With Atopic Dermatitis: A Review of Clinical Studies"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-6342","authenticated-orcid":false,"given":"Jacek C.","family":"Szepietowski","sequence":"first","affiliation":[{"name":"Division of Dermatology Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology  Wroclaw Poland"},{"name":"Department of Dermato\u2010Venereology 4th Military Hospital  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Tadini","sequence":"additional","affiliation":[{"name":"Center for Inherited Cutaneous Diseases, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13906"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12104"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.07.087"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17203"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3269"},{"key":"e_1_2_8_7_1","first-page":"141","article-title":"Recommendations for Managing Cutaneous Disorders Associated With Advancing Age","volume":"11","author":"Humbert P.","year":"2016","journal-title":"Clinical Interventions in Aging"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18429"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1607024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16892"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14891"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S389697"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17793"},{"key":"e_1_2_8_14_1","first-page":"664","article-title":"Evaluation of Efficacy and Safety of Dexeryl Cream in Symptomatic Treatment of Ichthyosis in a Single Blinded Randomised Comparative Study","volume":"19","author":"Blanchet\u2010Bardon C.","year":"2000","journal-title":"Nouvelles Dermatologiques"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04304.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05490610"},{"key":"e_1_2_8_17_1","first-page":"179","article-title":"Evaluation of a Skin Protection Cream for Dry Skin in Patients Undergoing Narrow Band UVB Phototherapy for Psoriasis Vulgaris","volume":"146","author":"Pacifico A.","year":"2011","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"key":"e_1_2_8_18_1","first-page":"297","article-title":"Efficacy of an Emollient Dermoprotective Cream in the Treatment of Elderly Skin Affected by Xerosis","volume":"150","author":"Cristaudo A.","year":"2015","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14095"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13454"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13163"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2011.628381"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-12-16"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1037731"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2010.12.004"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13402"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/opn.12145"},{"key":"e_1_2_8_28_1","first-page":"30","article-title":"A Prospective, Randomized, Controlled Double\u2010Blind Study of a Moisturizer for Xerosis of the Feet in Patients With Diabetes","volume":"48","author":"Pham H. 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