{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:12:19Z","timestamp":1778249539094,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human pyoderma gangrenosum (hPG) is a rare, non\u2010infectious neutrophilic dermatosis characterized by painful, necrotic ulcers with violaceous borders. Research on hPG is limited by minimal existing animal models, the sole being a pharmacologically induced murine model. Few cases of canine pyoderma gangrenosum (cPG) have been published, and dogs are genetically closer to humans than are mice, making them a potentially valuable model of hPG. We aimed to characterize all published cPG cases and compare their presentation to that of hPG. A Google Scholar, PubMed, and Embase search of \u201ccanine AND pyoderma gangrenosum\u201d was conducted in August 2024, with seven case reports, two case series, and two veterinarian\u2010sourced cases ultimately reviewed. Of the 31 analyzed cPG cases, 30 presented with skin ulcers at multiple sites, the most common being the trunk (64.5%), paws (41.9%), and limbs (32.3%), mirroring the typical localization of hPG on the lower extremities, back, and abdomen. The average age of cPG presentation was 7.8 +\/\u2212 3.7\u2009years (range: 0.25\u201314.5\u2009years). Dogs reflected hPG comorbidities, with 16.1% presenting with gastrointestinal pathologies, 6.5% with arthritis, and 6.5% with hematologic disorders. Dogs were responsive to medications frequently employed in hPG\u2014prednisone\/prednisolone (80.6%) as initial therapy, and cyclosporine (77.4%) as maintenance therapy. Overall, cPG resembles hPG in affected anatomic sites,\u00a0comorbidities, and therapeutic response. It offers a representative, spontaneously occurring hPG animal model alternative to the existing murine model. Future studies are necessary to reproduce cPG to further investigate disease pathophysiology.<\/jats:p>","DOI":"10.1111\/ijd.17863","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:08:16Z","timestamp":1747872496000},"page":"1584-1591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paws to Patients: Canine Pyoderma Gangrenosum as a Reflective Model of Human Pyoderma Gangrenosum"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5115-8762","authenticated-orcid":false,"given":"Kateryna","family":"Karpoff","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine Albert Einstein College of Medicine\/Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7765-9194","authenticated-orcid":false,"given":"Lori","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine L.","family":"Cain","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Becky","family":"Valentine","sequence":"additional","affiliation":[{"name":"PETDERM, Calgary Pet Dermatology Centre  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Dermatology VCA Aurora Animal Hospital  Aurora Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex G.","family":"Ortega\u2010Loayza","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12939"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S61202"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19\u20103\u2010224"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16401"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.04.019"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010023\u201001931\u20103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14221"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1148893"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.10.023"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.11.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crimmu.2021.03.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.894"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12065"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.21825\/vdt.v84i3.16605"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.21825\/vdt.v87i6.16052"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20105827.2006.00209.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12756"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.15\u20100724"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102174\u20106948"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.970"},{"issue":"1","key":"e_1_2_10_22_1","first-page":"65","article-title":"Antimicrobial Susceptibility of Staphylococcus pseudintermedius Colonizing Healthy Dogs in Saskatoon, Canada","volume":"57","author":"Priyantha R.","year":"2016","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.5978"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010animal\u2010051021\u2010080937"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14357"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/461467"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","unstructured":"S.Jatana A. 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