{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:35:32Z","timestamp":1792204532482,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder frequently associated with immune\u2010mediated comorbidities, including inflammatory bowel disease (IBD). Given the potential risk of IBD, particularly before initiating therapies such as interleukin (IL)\u201017 inhibitors, screening through a fecal calprotectin (FC) test may be warranted. While FC is a reliable, non\u2010invasive biomarker for ruling out IBD, its cost and limited availability in dermatology settings present challenges. Therefore, this study aims to investigate the potential association between FC and serum C\u2010reactive protein (CRP) levels in patients with moderate\u2010to\u2010severe HS, which may provide a more accessible screening approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This cross\u2010sectional cohort study was conducted at the Department of Dermatology and Venereology of U\u015fak University between April 2, 2024, and December 31, 2024, including 18\u201365\u2010year\u2010old patients with moderate\u2010to\u2010severe HS. Serum CRP and FC levels were analyzed using an enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Stool samples from 61 patients with moderate\u2010to\u2010severe HS were included. The median FC and serum CRP levels were 28.2\u2009\u03bcg\/g and 5.3\u2009mg\/L, respectively, with a significant correlation between them (rho\u2009=\u20090.289,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). While FC levels did not significantly differ between moderate and severe HS, CRP levels were significantly higher in patients with severe disease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Receiver operating characteristic (ROC) analysis identified a CRP cut\u2010off of 5.35\u2009mg\/L for predicting FC \u2265\u200950\u2009\u03bcg\/g (AUC\u2009=\u20090.660,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045), with 70% sensitivity and 61.5% specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with moderate\u2010to\u2010severe HS and serum CRP levels above 5.35\u2009mg\/L may benefit from FC screening, and those with FC levels exceeding 50\u2009\u03bcg\/g may be considered for further endoscopic evaluation to assess IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.17868","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:28:46Z","timestamp":1747873726000},"page":"1615-1622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum C\u2010Reactive Protein as a Potential Indicator for Screening Fecal Calprotectin in Patients With Moderate\u2010to\u2010Severe Hidradenitis Suppurativa: A Cross\u2010Sectional Cohort Study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-5481","authenticated-orcid":false,"given":"Neslihan","family":"Demirel \u00d6\u011f\u00fct","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine U\u015fak University  U\u015fak 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