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This study quantitatively evaluated the prevalence and odds of comorbidities among patients with LPP. PubMed\/MEDLINE, EMBASE, Cochrane Library, and Web of Science were searched from inception to December 25, 2023, to include observational studies reporting prevalent\/incident cases of at least one comorbidity in LPP patients. The study adhered to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses (PRISMA). Risk\u2010of\u2010bias assessment was performed using the Newcastle\u2010Ottawa scale. Random\u2010effect models were utilized to analyze available data. Of the 2535 studies screened, 59 studies were included for meta\u2010analysis, comprising 15,178 LPP patients and 64,735,181 non\u2010LPP controls. Among LPP patients, comorbidities with the highest risk (odds ratio, OR [95% confidence interval, Cl]; prevalence) compared with non\u2010LPP controls and data available from more than one study included lichen planus (15.78 [1.79\u2013139.30]; 6.5%), psoriasis (3.55 [1.10\u201311.51]; 4.3%), rosacea (3.15 [2.25\u20134.40]; 10.4%), melanoma (3.11 [1.41\u20136.87]; 2.3%), systemic lupus erythematosus (3.06 [2.29\u20134.09]; 1.8%), cutaneous squamous cell carcinoma (3.04 [1.64\u20135.66]; 4.8%), vitiligo (2.89 [1.60\u20135.24]; 2.0%), coronary artery disease (1.66 [1.46\u20131.88]; 7.6%), rheumatoid arthritis (1.50 [1.22\u20131.84]; 3.5%), hypothyroidism (1.48 [1.12\u20131.96]; 17.8%), thyroiditis (1.26 [1.08\u20131.48]; 3.9%), and iron deficiency anemia (1.18 [1.05\u20131.33]; 9.1%). LPP is significantly associated with autoimmune disorders, thyroid diseases, and skin cancer. Further investigation is required to elucidate the underlying pathogenesis and establish appropriate screening criteria.<\/jats:p>","DOI":"10.1111\/ijd.17925","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T23:04:01Z","timestamp":1751065441000},"page":"2257-2265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comorbidities Associated With Lichen Planopilaris: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1392-6395","authenticated-orcid":false,"given":"Li\u2010Chi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Lahey Hospital and Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1675-1705","authenticated-orcid":false,"given":"Chino","family":"Ogbutor","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lahey Hospital and Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunjeong","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Library Services Lahey Hospital and Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen J.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lahey Hospital and Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-520X","authenticated-orcid":false,"given":"Maryanne M.","family":"Senna","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lahey Hospital and Medical Center  Burlington Massachusetts USA"},{"name":"Department of Dermatology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4233"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.01.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153923"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17274"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12945"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17513"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.08.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.05.038"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2018.04.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad235"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2020.09.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16498"},{"key":"e_1_2_9_14_1","unstructured":"G. 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