{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:15:14Z","timestamp":1790111714023,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitiligo is an acquired depigmenting skin disorder characterized by autoimmune\u2010mediated melanocyte destruction, leading to well\u2010defined depigmented macules and patches. Localized non\u2010segmental vitiligo poses a significant therapeutic challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 251 patients with localized refractory non\u2010segmental vitiligo were randomized into four groups: combination therapy group (308\u2009nm excimer laser + Janus kinase [JAK]\u00a0inhibitors,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200963), JAK inhibitor monotherapy group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200963), 308\u2009nm excimer laser group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200963), and positive control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200962). Treatment lasted 52\u2009weeks. Therapeutic responses were assessed using the Vitiligo Area Scoring Index (VASI) and dermoscopy before and after treatment. Mixed\u2010effects models compared efficacy and analyzed influencing factors. Fisher's exact test compared efficacy among groups and sites; Kruskal\u2013Wallis test assessed melanocyte island density changes; chi\u2010square test evaluated pigmentation stability and recurrence at the 1\u2010year follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Combination therapy with 308\u2009nm excimer laser and oral JAK inhibitor baricitinib showed significantly greater efficacy than monotherapy and conventional treatment, with a 14.20% higher repigmentation rate than the positive control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), indicating synergistic effects. By Week 4, patients with melanocyte island density \u2265\u20095\/cm\n                      <jats:sup>2<\/jats:sup>\n                      had markedly better repigmentation, supporting dermoscopy as an early predictive and monitoring tool. Mixed\u2010effects analysis showed higher repigmentation in facial versus non\u2010facial lesions, females vs. males, and reduced efficacy with longer disease duration. At the 1\u2010year follow\u2010up, combination therapy maintained stable pigmentation with no recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of 308\u2009nm excimer laser and JAK inhibitors significantly enhances repigmentation efficiency in adult localized non\u2010segmental vitiligo, particularly in patients with shorter disease duration and early formation of pigment islands.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.17973","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T08:03:35Z","timestamp":1752912215000},"page":"2283-2291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["308\u2009nm Excimer Laser Combined With\n                    <scp>JAK<\/scp>\n                    Inhibitors for Adult Localized Non\u2010Segmental Vitiligo: A Multicenter Randomized Controlled Trial"],"prefix":"10.1111","volume":"64","author":[{"given":"Zuoyao","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Xuzhou Medical University  Xuzhou 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