{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:50:33Z","timestamp":1790279433733,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lichen planopilaris (LPP) and folliculitis decalvans (FD) are two of the most common types of primary scarring alopecia. Several Janus kinase inhibitors (JAKis) have been used effectively in their treatment. We conducted an immunohistochemical (IHC) study to evaluate whether any member of the JAK family was overexpressed in the primary inflammatory infiltrate of FD and LPP. Additionally, we performed an exploratory retrospective study on the efficacy and safety of oral JAKis in LPP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pathology scalp samples from seven healthy controls and 28 patients with LPP or FD were selected for staining with anti\u2010JAK1, anti\u2010JAK2, anti\u2010JAK3, and anti\u2010TYK2 antibodies. Cases and controls were compared using the H\u2010score of the inflammatory cells. On the other hand, an exploratory retrospective clinical study was conducted in which patients with LPP who were treated with JAKis for at least three months were included. Clinical characteristics, severity scores, and the presence of adverse events were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The IHC study determined that JAK1 and JAK2 exhibited similar expression patterns in cases and controls. However, JAK3 and TYK2 were expressed solely in cases of primary scarring alopecia and were negative in the controls. In the exploratory clinical study, 19 patients with LPP were treated with JAKis. Severity scores improved in follow\u2010up visits, with adverse events generally being mild.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>JAK3 and TYK2 were overexpressed in LPP and FD samples compared to healthy controls, supporting JAKs as potential pharmacological targets of interest. JAKis could be an effective and safe treatment for LPP patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70084","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:01:19Z","timestamp":1759204879000},"page":"2266-2273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Immunohistochemical Characterization of\n                    <scp>JAK<\/scp>\n                    Family Expression in the Primary Inflammatory Infiltrate of Lichen Planopilaris and Folliculitis Decalvans, With an Exploratory Clinical Assessment of Oral\n                    <scp>JAK<\/scp>\n                    Inhibitors"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7429-9592","authenticated-orcid":false,"given":"Miguel Antonio","family":"Lasheras\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Dermatology Department La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Concepci\u00f3n","family":"Garrido\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Pathology Department 12 de Octubre University Hospital  Madrid Spain"},{"name":"Institute I+12  Madrid Spain"},{"name":"Pathology Department Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Lobato\u2010Berezo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8353-7481","authenticated-orcid":false,"given":"Rodolfo David","family":"Palacios\u2010Diaz","sequence":"additional","affiliation":[{"name":"Dermatology Department La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Albert\u2010Cobo","sequence":"additional","affiliation":[{"name":"Dermatology Department Dr. Balmis General Hospital  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-4467","authenticated-orcid":false,"given":"Giuseppe","family":"Gallo","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Velasco\u2010Tamariz","sequence":"additional","affiliation":[{"name":"Institute I+12  Madrid Spain"},{"name":"Dermatology Department 12 de Octubre University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Ruiz\u2010Villaverde","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital San Cecilio  Granada Spain"},{"name":"Instituto Biosanitario de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-0402","authenticated-orcid":false,"given":"Roc\u00edo","family":"Gil\u2010Redondo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Pujol\u2010Marco","sequence":"additional","affiliation":[{"name":"Dermatology Department La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"Garc\u00eda\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Pathology Department 12 de Octubre University Hospital  Madrid Spain"},{"name":"Institute I+12  Madrid Spain"},{"name":"Pathology Department Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Mar","family":"Blanes\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Dermatology Department Dr. Balmis General Hospital  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Escutia\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Dermatology Department La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-6962","authenticated-orcid":false,"given":"Jorge","family":"Magdaleno\u2010Tapial","sequence":"additional","affiliation":[{"name":"Dermatology Department Valencia General Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rodr\u00edguez\u2010Serna","sequence":"additional","affiliation":[{"name":"Dermatology Department La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sahuquillo\u2010Torralba","sequence":"additional","affiliation":[{"name":"Dermatology Department La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-1406","authenticated-orcid":false,"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Gelato","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Llavador\u2010Ros","sequence":"additional","affiliation":[{"name":"Pathology Department La Fe University and Polytechnic Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicent","family":"Mart\u00ednez\u2010C\u00f3zar","sequence":"additional","affiliation":[{"name":"Pathology Department La Fe University and Polytechnic Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolay S.","family":"Pantoja Borja","sequence":"additional","affiliation":[{"name":"Pathology Department La Fe University and Polytechnic Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen I.","family":"Lo Sicco","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Shapiro","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Rodr\u00edguez\u2010Peralto","sequence":"additional","affiliation":[{"name":"Pathology Department 12 de Octubre University Hospital  Madrid Spain"},{"name":"Institute I+12  Madrid Spain"},{"name":"Pathology Department Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Botella\u2010Estrada","sequence":"additional","affiliation":[{"name":"Dermatology Department La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute Hospital La Fe  Valencia Spain"},{"name":"University of Valencia, Department of Dermatology  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2014.06.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.68"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.3062"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00630-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.050"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.09.073"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.03.092"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v104.12373"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001595"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17339"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13786"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.01.060"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.955035"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0474-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02412.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.032"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.054"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500973"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.142205"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.06.097"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1309\/NG60Y7V0WNUFH4LA"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgac111"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.05.016"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4233"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010119"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.159566"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.12.014"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19040"},{"issue":"10","key":"e_1_2_8_30_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164080","article-title":"JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases","volume":"11","author":"De Medeiros A. K. A.","year":"2016","journal-title":"PLoS One"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.46.3.258"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043391"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.05.104"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17681"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.02.027"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13968"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15900"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030824"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.70084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T08:16:46Z","timestamp":1762935406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.70084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/ijd.70084"],"URL":"https:\/\/doi.org\/10.1111\/ijd.70084","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"2025-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}