{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:43:30Z","timestamp":1772984610778,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Leprosy, caused by\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Mycobacterium leprae<\/jats:italic>\n                      <\/jats:styled-content>\n                      , leads to peripheral neuropathy and significant functional disability if its diagnosis is delayed. Infrared thermography may offer a non\u2010invasive method for the detection of neurological complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted with 100 leprosy patients and 20 healthy controls. Participants were assessed for cutaneous temperature using infrared thermography at defined areas corresponding to peripheral nerve innervation points (hands, feet, and face). Sensory neuropathy was analyzed using the Semmes\u2013Weinstein (SW) monofilament test, while autonomic nerve dysfunction was evaluated through the sympathetic skin response (SSR). Data were analyzed with the aim of verifying whether changes in skin temperature clinically correlated with sensory loss, autonomic nerve dysfunction, and distinct forms of the leprosy spectrum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Leprosy patients had significantly lower skin temperature compared to controls, with a mean temperature of 32.5\u00b0C\u2009\u00b1\u20092.3\u00b0C vs. 35.2\u00b0C\u2009\u00b1\u20090.4\u00b0C for hands (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 24.1\u00b0C\u2009\u00b1\u20092.8\u00b0C vs. 34.8\u00b0C\u2009\u00b1\u20090.5\u00b0C for feet (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Temperature differences were most pronounced in body areas showing sensory neuropathy (e.g., 30.1\u00b0C\u2009\u00b1\u20092.2\u00b0C for hands with absent sensation vs. 34.1\u00b0C\u2009\u00b1\u20091.6\u00b0C with normal sensation,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Strong linear correlations were found between cutaneous temperature and sensory loss assessed using SW filaments (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and between cutaneous temperature and SSR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Disability grade also correlated with lower temperatures, with hands at 34.3\u00b0C for no disability, 31.3\u00b0C for Grade 1, and 31.5\u00b0C for Grade 2 disability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Infrared thermography is a promising, non\u2010invasive tool for the detection of peripheral sensory impairment in leprosy. The results obtained by infrared thermography show a strong correlation with those obtained using standard tests for sensory loss and autonomic nerve dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70099","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:54:40Z","timestamp":1760712880000},"page":"563-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infrared Thermography for Detection of Neural Impairment in Leprosy: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-6018","authenticated-orcid":false,"given":"Narayanan","family":"Baskaran","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Neurology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Cazzaniga","sequence":"additional","affiliation":[{"name":"Centro Studi GISED  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Borradori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Inselspital University Hospital of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-4988","authenticated-orcid":false,"given":"Keshavamurthy","family":"Vinay","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-0085","authenticated-orcid":false,"given":"Sunil","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142450"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization (WHO) \u201cWeekly Epidemiological Record \u201dWER No 37 2024 99 501\u2013521 https:\/\/iris.who.int\/bitstream\/handle\/10665\/378895\/WER9937\u2010501\u2010521.pdf?sequence=1."},{"key":"e_1_2_10_4_1","volume-title":"Towards Zero Leprosy. 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