{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:08:38Z","timestamp":1789924118462,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin barrier dysfunction is a key driver of skin sensitivity and inflammatory dermatoses. However, the long\u2010term efficacy of existing moisturizers remains limited. This study aimed to evaluate the efficacy of a moisturizer formulated with target skin disruption, lock in moisture, connect skin cells (TLC) technology using in\u00a0vitro and clinical evaluations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The efficacy of the TLC complex was assessed through ultraviolet A (UVA)\u2013induced full\u2010thickness skin, sodium lauryl sulfate (SLS)\u2013damaged epidermis, and capsaicin\u2010stimulated keratinocytes in\u00a0vitro. Clinical evaluations were conducted to comprehensively assess the soothing effects, hydration enhancement, and barrier repair of the TLC technology\u2013based moisturizer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The TLC complex significantly suppressed the expression of nuclear factor kappa B, transient receptor potential vanilloid 1, interleukin\u20101\u03b1, prostaglandin E2, and vascular endothelial growth factor (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). It also markedly increased aquaporin\u20103, natural moisturizing factor levels, and the ceramide\u2010to\u2010protein ratio (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The expression of key barrier proteins, including filaggrin, loricrin, involucrin, keratin 10, corneodesmosin, claudin\u20101, and laminin\u20105, was significantly restored (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Clinically, the TLC moisturizer significantly reduced facial redness proportion,\n                      <jats:italic>a<\/jats:italic>\n                      * value, erythema index, and Sensitive Scale\u201010 score (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A single application markedly boosted hydration and reduced transepidermal water loss (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The moisturizer also significantly accelerated barrier repair in SLS\u2010damaged skin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The TLC\u2010based moisturizer demonstrated comprehensive anti\u2010inflammatory, hydrating, and barrier\u2010restoring effects in preclinical and clinical evaluations, supporting its use as a safe and effective adjuvant therapy for individuals with sensitive or compromised skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70114","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:30:55Z","timestamp":1765974655000},"page":"33-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Moisturizer Based on Multi\u2010Targeted Skin Barrier Repair Conception: Evidence From In\u00a0Vitro and Clinical Evaluations"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6135-7743","authenticated-orcid":false,"given":"Bohan","family":"Xu","sequence":"first","affiliation":[{"name":"Medical Affairs Galderma China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8607-900X","authenticated-orcid":false,"given":"Yinjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Affairs Galderma China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8831-5899","authenticated-orcid":false,"given":"Jie","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital, Fudan University  Shanghai 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