{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:22:13Z","timestamp":1781112133736,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Guselkumab, a selective interleukin (IL)\u201023 inhibitor, is approved for the treatment of moderate\u2010to\u2010severe plaque psoriasis. While randomized clinical trials have introduced the concept of \u201csuper\u2010responders\u201d (SRe)\u2014patients achieving complete skin clearance (Psoriasis Area and Severity Index [PASI] 100) at defined early timepoints\u2014real\u2010world evidence on their characteristics and long\u2010term outcomes remains limited. This study aimed to identify baseline predictors of super\u2010response (PASI 100 at Weeks 16 and 24) and to evaluate long\u2010term effectiveness, safety, and drug survival over a 5\u2010year period in a routine clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter study analyzed 435 patients from the Czech BIOREP registry treated with guselkumab. Predictors of super\u2010response were identified using multivariable logistic regression. PASI outcomes and drug survival were assessed with descriptive statistics and Kaplan\u2013Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the cohort, 130 patients (29.9%) were classified as super\u2010responders. Lower body mass index (BMI) and absence of prior biologic therapy were independent predictors of SRe status (odds ratio [OR]\u2009=\u20090.94 and 0.73, respectively). While PASI 75\/90\/100 rates were significantly higher in SRe throughout follow\u2010up, drug survival was comparable between SRe and non\u2010SRe. At 60\u2009months, PASI 100 was maintained in 79.2% of SRe versus 35.4% of non\u2010SRe. Obesity and female sex were associated with lower long\u2010term treatment persistence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Super\u2010response to guselkumab is linked to distinct baseline features. Despite differences in PASI outcomes, treatment persistence was similar across groups. These findings underscore the value of early identification of super\u2010responders and support personalized treatment strategies in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70126","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:11:11Z","timestamp":1761973871000},"page":"980-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Super\u2010Response to Guselkumab Treatment in Patients With Moderate\u2010to\u2010Severe Psoriasis: Real\u2010World Data With Up to Five Years of Follow\u2010Up in The Czech Republic"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-9965","authenticated-orcid":false,"given":"Martina","family":"Kojanova","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology, First Faculty of Medicine and General University Hospital Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pejrilova","sequence":"additional","affiliation":[{"name":"Value Outcomes  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorga","family":"Fialova","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, First Faculty of Medicine and General University Hospital Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-6768","authenticated-orcid":false,"given":"Petra","family":"Cetkovska","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, Faculty of Medicine and University Hospital in Pilsen Charles University  Pilsen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Gkalpakiotis","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, Third Faculty of Medicine and Kralovske Vinohrady University Hospital Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Machovcova","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology University Hospital Motol  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Arenberger","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, Third Faculty of Medicine and Kralovske Vinohrady University Hospital Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Stork","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, First Faculty of Medicine and General University Hospital Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Dolezal","sequence":"additional","affiliation":[{"name":"Value Outcomes  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Tichy","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine and Dentistry Palacky University Olomouc  Olomouc Czech Republic"},{"name":"Department of Dermatology and Venereology University Hospital Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the BIOREP study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"issue":"8","key":"e_1_2_9_3_1","first-page":"891","article-title":"The Risk of Depression, Anxiety, and Suicidality in Patients With Psoriasis: A Population\u2010Based Cohort Study","volume":"146","author":"Kurd S. 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