{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:12:36Z","timestamp":1784542356664,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alopecia areata (AA) is a chronic inflammatory disease characterized by non\u2010scarring hair loss, which can markedly affect the quality of life (QoL) of children. The absence of disease\u2010specific instruments to measure this impact motivated the development of the Alopecia Areata Children's Quality of Life Index (AAcQLI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study aims to develop and validate a disease\u2010specific instrument to assess QoL in children with AA, addressing emotional, social, and functional domains. The AAcQLI was developed through a review of existing instruments, refined by an expert committee, and tested in a pilot sample. Its psychometric properties were evaluated by examining content and construct validity, while reliability was assessed through test\u2013retest and internal consistency using Cronbach's \u03b1 coefficient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study sample comprised 20 children, with a median age of 9.5\u2009years (interquartile range [IQR]\u2009=\u20097.5\u201313). The AAcQLI demonstrated good internal consistency (Cronbach's \u03b1\u2009=\u20090.86) and excellent content validity (Content Validity Index\u2009=\u20091.0). Convergent validity indicated fair agreement with the Children's Dermatology Life Quality Index (CDLQI) (\n                      <jats:italic>k<\/jats:italic>\n                      \u2009=\u20090.24) and slight agreement, as measured by the Severity of Alopecia (SALT) (\n                      <jats:italic>k<\/jats:italic>\n                      \u2009=\u20090.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The AAcQLI is a promising tool for assessing quality of life in children with AA. Further studies with larger and more diverse populations are warranted to refine its measurement properties and strengthen its clinical applicability in evaluating the psychosocial impact of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70173","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T04:41:31Z","timestamp":1764391291000},"page":"1225-1230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of the\n                    <scp>AAcQLI<\/scp>\n                    : A New Instrument for Assessing Quality of Life in Children With Alopecia Areata"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8098-5051","authenticated-orcid":false,"given":"Izabella","family":"Rodrigues Reis Gomes","sequence":"first","affiliation":[{"name":"Postgraduate Program in Child and Adolescent Health Complexo Hospital de Cl\u00ednicas of Federal University of Parana, UFPR  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-3540","authenticated-orcid":false,"given":"Mariana Aparecida","family":"Pasa Morgan","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Child and Adolescent Health Complexo Hospital de Cl\u00ednicas of Federal University of Parana, UFPR  Curitiba Brazil"},{"name":"Ceres Faculty \u2010 Medical School  S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6069-5743","authenticated-orcid":false,"given":"Luiza","family":"Kalil","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale University School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4816-0057","authenticated-orcid":false,"given":"Priscila Vernizi","family":"Roth","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics Complexo Hospital de Cl\u00ednicas of Federal University of Parana, UFPR  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6586-3208","authenticated-orcid":false,"given":"Susana","family":"Giraldi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics Complexo Hospital de Cl\u00ednicas of Federal University of Parana, UFPR  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4578-8781","authenticated-orcid":false,"given":"V\u00e2nia","family":"Oliveira Carvalho","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics Complexo Hospital de Cl\u00ednicas of Federal University of Parana, UFPR  Curitiba 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