{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:11:46Z","timestamp":1784542306718,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100013226","name":"Les Laboratories Pierre Fabre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Commensal bacteria interact with each other and their environment, secreting anti\u2010microbial peptides, bacteriocins, and extracellular vesicles (EVs).\n Cutibacterium acnes<\/jats:italic>\n (\n C. acnes<\/jats:italic>\n ), a commensal bacterium that plays a major role in acne, is classified into different phylotypes (\n IA<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sub>\n ,\n IA<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sub>\n ,\n IB<\/jats:italic>\n ,\n IC<\/jats:italic>\n ,\n II<\/jats:italic>\n , and\n III<\/jats:italic>\n ), where overabundance of phylotype\n IA<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sub>\n relative to other phylotypes is found in acne lesions. EVs secreted by\n C. acnes<\/jats:italic>\n phylotype\n IA<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sub>\n extracted from an acne lesion were previously found to induce a pro\u2010inflammatory response in skin models. Here, we investigated the effects of\n \n Myrtus communis<\/jats:italic>\n <\/jats:styled-content>\n extract (Myrtacine) and Celastrol\u2010enriched extract (CEE), anti\u2010inflammatory ingredients, alone or in combination, on cutaneous innate immunity induced by\n C. acnes IA<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sub>\n EVs.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study was conducted under preventive and modulating conditions: Myrtacine alone, CEE alone, or in combination were added to the culture medium either prior to (preventive) or after (modulating) incubation with\n C. acnes IA<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sub>\n EVs from healthy and acne skin in immortalized keratinocytes (HaCaT) and human skin explants. Then, regulation of \u03b2\u2010defensin 2 (hBD2), interleukin (IL)\u20106, IL\u20108, IL\u201017\u03b1, and IL\u201036\u0263 was assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Preventive and modulating applications of Myrtacine and CEE significantly reduced expression of the five immune markers induced specifically by EVs from acne\u2010derived\n C. acnes IA<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our results show that\n C. acnes<\/jats:italic>\n EVs may be a target of Myrtacine and CEE. They can down\u2010modulate the pro\u2010inflammatory activity induced by EVs derived from\n C. acnes IA<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sub>\n from acne skin, showing the interest of these ingredients at both preventive and modulating levels in the treatment of inflammatory acne.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijd.70188","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T05:17:17Z","timestamp":1765948637000},"page":"1215-1224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Myrtacine and Celastrol\u2010Enriched Extract on\n \n Cutibacterium acnes<\/i>\n <\/scp>\n Extracellular Vesicles"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7119-4896","authenticated-orcid":false,"given":"Caroline T.","family":"Cheung","sequence":"first","affiliation":[{"name":"Nantes University, INSERM, CNRS Immunology and New Concepts in ImmunoTherapy (INCIT) Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-8255","authenticated-orcid":false,"given":"C\u00e9line","family":"Mias","sequence":"additional","affiliation":[{"name":"Pierre Fabre Dermo\u2010Cosm\u00e9tique et Personal Care Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-5510","authenticated-orcid":false,"given":"Ugo","family":"Lancien","sequence":"additional","affiliation":[{"name":"Nantes University CHU Nantes Chirurgie Plastique, Reconstructrice et Esth\u00e9tique et Centre de Traitement Des Br\u00fbl\u00e9s Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-8111","authenticated-orcid":false,"given":"St\u00e9phane","family":"Corvec","sequence":"additional","affiliation":[{"name":"CHU Nantes Bacteriology Department Nantes University Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-3974","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"Medical Direction Laboratoires Dermatologiques Ducray Lavaur France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-8004","authenticated-orcid":false,"given":"Amir","family":"Khammari","sequence":"additional","affiliation":[{"name":"Nantes University, INSERM, CNRS Immunology and New Concepts in ImmunoTherapy (INCIT) Nantes France"},{"name":"Department of Dermatology Nantes University, CHU Nantes, INSERM Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-8070","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Duplan","sequence":"additional","affiliation":[{"name":"Pierre Fabre Dermo\u2010Cosm\u00e9tique et Personal Care Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-5825","authenticated-orcid":false,"given":"Brigitte","family":"Dr\u00e9no","sequence":"additional","affiliation":[{"name":"Nantes University, INSERM, CNRS Immunology and New Concepts in ImmunoTherapy (INCIT) Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102847"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioflm.2021.100063"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15795"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/MICROORGANISMS9020303"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17194"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2007.02.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41579\u2010023\u201000875\u20105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3480"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598\u2010023\u201043354\u2010W"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010022\u201001472\u20103"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105797"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.01.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15150"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101270955"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.11.016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1111798"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672\u2010024\u201001045\u20106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.18793"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16475"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.02.029"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116256"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2095\u20104964(16)60257\u20101"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114705"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.70188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.70188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.70188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:59:05Z","timestamp":1784541545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.70188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,16]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ijd.70188"],"URL":"https:\/\/doi.org\/10.1111\/ijd.70188","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,16]]},"assertion":[{"value":"2025-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}