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This study assessed the association between carrier status of PV\/LPV in skin CPGs and FBSEs and described the patterns of family letter receipt, familial disclosure, and cascade testing among high\u2010risk individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between July and September 2023, we surveyed participants enrolled in the Chicago Cancer Prone Study. Carrier status of PV\/LPV in skin CPGs was defined as having been told by a genetic counselor that they have a PV\/LPV in\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      ,\n                      <jats:italic>TP53<\/jats:italic>\n                      ,\n                      <jats:italic>PTEN<\/jats:italic>\n                      ,\n                      <jats:italic>BRIP1<\/jats:italic>\n                      ,\n                      <jats:italic>PALB2<\/jats:italic>\n                      ,\n                      <jats:italic>ATM<\/jats:italic>\n                      , and\/or\n                      <jats:italic>CHEK2<\/jats:italic>\n                      genes. FBSEs were assessed by asking individuals whether they ever had an FBSE and modeled using logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 579 individuals (mean age, 59.5\u2009years), 11.6% carry PV\/LPV in skin CPGs and 63.8% ever had a FBSE. Carriers had greater odds of FBSEs than non\u2010carriers (adjusted odds ratio, 2.15; 95% CI, 1.03\u20134.52). White race, older age, and female sex were associated with increased odds of FBSEs. Among carriers, 65.3% received a family letter from their genetic counselor after testing; 91.0% disclosed their PV\/LPV\u2010carrying status to any family members, and 62.7% of the individuals' family members underwent genetic testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found greater odds of FBSEs among PV\/LPV carriers, notable disparities in FBSEs, and prevalent family letter receipt, familial disclosure, and cascade testing. This study highlights the role of PV\/LPV\u2010carrying status on FBSEs and the potential need for comprehensive guidelines beyond known risk factors to optimize skin cancer screening in high\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70206","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T05:15:24Z","timestamp":1765430124000},"page":"1431-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skin Cancer Predisposition Genes, Full\u2010Body Skin Examinations, Familial Disclosure, and Genetic Testing Among High\u2010Risk Individuals"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1119-2146","authenticated-orcid":false,"given":"Jincong Q.","family":"Freeman","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences The University of Chicago  Chicago Illinois 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