{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:53:11Z","timestamp":1790146391707,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ablative laser therapy is an interventional dermatological tool mainly used for removal of skin lesions, skin rejuvenation and scar treatment. The biomolecular changes following laser therapy are yet not fully understood. This scoping review provides an overview of the molecular changes upon (fractional) ablative laser therapy. Pubmed, Embase and Web of Science were systematically searched, focusing on changes in gene and protein expression. In total, 20 studies were included, involving a variety of laser devices (10,600\u2009nm CO\n                    <jats:sub>2<\/jats:sub>\n                    laser, 2940\u2009nm Er:YAG laser, 2790\u2009nm Er:YSGG laser). Most studies concerned ablative laser therapy for skin rejuvenation. Both fractional and full ablative laser induced a wound\u2010healing response with dermal remodeling and neocollagenesis, characterized by an increase in metalloproteinases and collagen. The inflammatory phase was more pronounced after ablative laser compared to fractional therapy, with more pronounced expression of innate immune\u2010related genes. High collagen type I, III, VII protein levels persisted for 6\u2009months following both full and fractional ablative laser. Old elastic fibers were degraded by laser therapy, followed by formation of new elastic fibers, as indicated by tropoelastin increase. Elastogenesis was more pronounced after full ablation. Interestingly, Er:YAG minipeels, ablating the epidermis while preserving the basal membrane, showed similar biomolecular changes compared to full ablation of the epidermis and superficial dermal layer.\n                  <\/jats:p>","DOI":"10.1111\/ijd.70225","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T04:55:28Z","timestamp":1767502528000},"page":"753-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biomolecular Changes Upon Ablative Laser Therapy of the Skin: A Scoping Review"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2028-2973","authenticated-orcid":false,"given":"Marie\u2010Eline Pauline Henriette","family":"Debeuf","sequence":"first","affiliation":[{"name":"Department of Dermatology, Centre of Expertise for Genodermatoses Maastricht University Medical Centre+  Maastricht the Netherlands"},{"name":"GROW Research Institute for Oncology and Developmental Biology Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje Hendrika Pieternel","family":"Rauwenhoff","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre of Expertise for Genodermatoses Maastricht University Medical Centre+  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0273-8020","authenticated-orcid":false,"given":"Michel","family":"van Geel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre of Expertise for Genodermatoses Maastricht University Medical Centre+  Maastricht the Netherlands"},{"name":"GROW Research Institute for Oncology and Developmental Biology Maastricht University  Maastricht the Netherlands"},{"name":"Department of Clinical Genetics Maastricht University Medical Centre+  Maastricht the 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Netherlands"},{"name":"Dermadok Huidkliniek  Antwerp 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