{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:08:36Z","timestamp":1790352516872,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin disease with significant physical and psychosocial burden. Dupilumab, a monoclonal antibody targeting IL\u20104R\u03b1, has proven to be effective for moderate\u2010to\u2010severe AD, but long\u2010term real\u2010world data remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to evaluate the long\u2010term effectiveness, safety, and achievement of minimal disease activity (MDA) in patients with moderate\u2010to\u2010severe AD treated with dupilumab over a 5\u2010year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective single\u2010center cohort study was conducted at the Dermatologic Clinic of the University of Turin, including 583 patients aged\u2009\u2265\u20096\u2009years treated with dupilumab between November 2018 and January 2025. Effectiveness was measured by Eczema Area and Severity Index (EASI), Pruritus\u2010Numerical Rating Scale (P\u2010NRS), and Sleep Loss\u2010Numerical Rating Scale (S\u2010NRS) scores, Dermatology Life Quality Index (DLQI). MDA was defined as EASI\u201090 combined with P\u2010NRS\u2009\u2264\u20091. Safety and drug survival were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dupilumab treatment resulted in significant and sustained reductions in EASI and symptom scores over 5\u2009years. The proportion of patients achieving MDA increased from 22.0% at 16\u2009weeks to 56.0% at 208\u2009weeks and remained stable at 55.3% through 5\u2009years. Male sex and childhood onset may reduce treatment success, warranting further study. The safety profile was favorable, with low discontinuation rates, and conjunctivitis as the most common adverse event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our long\u2010term real\u2010world data support the sustained effectiveness and safety of dupilumab in moderate\u2010to\u2010severe AD, with over 55% of patients achieving and maintaining MDA at 5\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70260","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:19:36Z","timestamp":1768375176000},"page":"1846-1855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Minimal Disease Activity as A New Therapeutic Target in Atopic Dermatitis: A 5\u2010Year Real\u2010Life Experience With Dupilumab"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4529-7068","authenticated-orcid":false,"given":"Francesco","family":"Leo","sequence":"first","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Mastorino","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cangialosi","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Favre","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences University of Turin  Turin 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