{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:00:14Z","timestamp":1785798014855,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary cicatricial alopecias (PCA) are rare inflammatory disorders that irreversibly destroy hair follicles, making early, accurate diagnosis crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to describe line field confocal optical coherence tomography (LC\u2010OCT) features of major PCA subtypes and assess its potential role in diagnosis and disease monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010five patients with PCA (lichen planopilaris [LPP], frontal fibrosing alopecia [FFA], folliculitis decalvans [FD], discoid lupus erythematosus [DLE], dissecting cellulitis of the scalp [DCS]) underwent LC\u2010OCT imaging with vertical, horizontal, and 3D acquisitions of clinically and trichoscopically selected lesions. Images were independently evaluated to identify both shared and subtype\u2010specific patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In active lesions of LPP\/FFA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915), infundibular hyperkeratosis with hyper\u2010reflective keratinous sleeves was observed in 14\/15 (93.3%), perifollicular bright inflammatory aggregates in 7\/15 (46.6%), and dilated dermal vessels in 9\/15 (60.0%). DLE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) was characterized by periadnexal inflammation, basal vacuolar alteration, and a continuous hyper\u2010reflective junctional band in 4\/4 (100%), dermal hyporeflective bands compatible with mucin in 2\/4 (50.0%), and follicular plugs in 2\/4 (50.0%). FD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) demonstrated tufted follicles with markedly dilated infundibula in 3\/4 (75.0%), pustule\u2010like hyporeflective cavities in 2\/4 (50.0%), and periadnexal inflammatory infiltrates in 3\/4 (75.0%). DCS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) showed superficial abscess\u2010like lobulated hyporeflective cavities with perifollicular inflammatory clusters in 2\/2 (100%) and follicular fusion with hair tufting in 1\/2 (50.0%). In end\u2010stage cicatricial areas, LC\u2010OCT demonstrated follicular dropout with loss of sebaceous glands, dermal sclerosis forming a stellate pattern, and a flattened, hyper\u2010reflective dermal\u2013epidermal junction in all 25\/25 cases (100%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LC\u2010OCT identifies shared scarring signatures as well as distinct patterns among PCA subtypes, and it supports targeted biopsy site selection. Moreover, it provides a noninvasive tool for real\u2010time assessment of disease activity that is complementary to trichoscopy and histopathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70266","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:57:48Z","timestamp":1768381068000},"page":"1641-1646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Line Field Confocal Optical Coherence Tomography (\n                    <scp>LC<\/scp>\n                    \u2010\n                    <scp>OCT<\/scp>\n                    ) Features of Primary Cicatricial Alopecias"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7926-3389","authenticated-orcid":false,"given":"Daniele Omar","family":"Traini","sequence":"first","affiliation":[{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"},{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli \u2013 IRCCS  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"},{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli \u2013 IRCCS  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7198-4273","authenticated-orcid":false,"given":"Irina","family":"Ciobotariu","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"},{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli \u2013 IRCCS  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Casciola","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"},{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli \u2013 IRCCS  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1746-2708","authenticated-orcid":false,"given":"Lorenzo Maria","family":"Pinto","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"},{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli \u2013 IRCCS  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Suppa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Department of Dermato\u2010Oncology, Institut Jules Bordet Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Groupe D'imagerie Cutan\u00e9e Non Invasive (GICNI) of the Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie (SFD)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Di Stefani","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"},{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. 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