{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:03:28Z","timestamp":1790813008569,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin disease that significantly impairs quality of life, particularly in adolescents, a period marked by intense physical and psychosocial development. The burden of AD extends beyond dermatological symptoms, with growing evidence linking the condition to mental health disorders. As real\u2010world data focused specifically on adolescent populations is scarce, this study aimed to evaluate the risk of psychiatric comorbidities among AD adolescents using a large electronic health records database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study utilizing the TriNetX Analytics platform, including adolescents aged 10\u201318\u2009years diagnosed with AD was conducted. Individuals with pre\u2010existing psychiatric disorders were excluded. A matched control group was identified; propensity score matching (1:1) accounted for demographic, socioeconomic, and major systemic comorbidities. Incident psychiatric outcomes were captured using ICD\u201010 codes and analyzed with Cox proportional hazards models. Sensitivity and sex\u2010stratified analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, 262,558 adolescents were included in each cohort. AD was associated with a significantly increased risk of any psychiatric disorder (17.3% vs. 6.2%; hazard ratio [HR]\u2009=\u20093.00, 95% confidence interval [CI]: 2.95\u20133.06). Anxiety (HR\u2009=\u20092.72), depression (HR\u2009=\u20092.66), sleep disorders (HR\u2009=\u20091.49), personality disorders (HR\u2009=\u20094.31), suicidality (HR\u2009=\u20091.62), and self\u2010harm (HR\u2009=\u20091.47) were notably elevated. Findings remained consistent across sensitivity analyses. Female adolescents showed disproportionately higher risks of depression, anxiety, eating disorders, and self\u2010harm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adolescents with AD exhibit a markedly elevated risk of diverse psychiatric disorders, with pronounced vulnerability among girls. These results highlight the importance of integrated dermatologic and psychological care to support mental health in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70301","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:02:26Z","timestamp":1769504546000},"page":"1864-1872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Psychiatric Comorbidities in Adolescents With Atopic Dermatitis: A Real\u2010World Study of Propensity\u2010Matched Cohorts"],"prefix":"10.1111","volume":"65","author":[{"given":"Marta","family":"Szepietowska","sequence":"first","affiliation":[{"name":"Department of Dermatology Jagiellonian University Medical College  Krak\u00f3w Poland"},{"name":"Doctoral School of Medical and Health Sciences Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr K.","family":"Krajewski","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine Wroclaw University of Science and Technology  Wroclaw Poland"},{"name":"Department of Dermato\u2010Venereology 4th Military Hospital  Wroclaw Poland"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemyslaw","family":"Pacan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Medical Sciences Rzeszow University  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wojas\u2010Pelc","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej K.","family":"Jaworek","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2023911"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20639"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00819-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19580"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-13650-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2024.16.3.300"},{"issue":"2","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jaad.2025.10.022","article-title":"Prevalence of Atopic Dermatitis in the United States From 2021 to 2024: Data From the National Health Interview Survey","volume":"94","author":"Chan K. 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