{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:08:47Z","timestamp":1784131727077,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Actinic keratoses (AKs) are ultraviolet (UV)\u2010induced skin lesions that may progress to invasive squamous cell carcinoma. Hyperkeratotic AKs hinder line\u2010field confocal optical coherence tomography (LC\u2010OCT) imaging, limiting assessment of the dermal\u2010epidermal junction (DEJ) and PRO\u2010score, a histopathological index of dermal invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate whether moisturization improves DEJ visualization and PRO\u2010score evaluation in hyperkeratotic AKs using LC\u2010OCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Fifty\u2010nine hyperkeratotic AKs were randomized to receive either 20\u2010min tap water occlusion or 20% salicylic acid ointment (SAO). LC\u2010OCT scans were taken before and after treatment. DEJ visibility, PRO\u2010score (0\u20133), and confidence in PRO assignment (cPRO) were rated by blinded evaluators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DEJ visibility significantly increased posttreatment (from 39.0% to 86.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015), with no significant difference between water and salicylic acid ointment (SAO). Confidence in PRO\u2010scoring also improved (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and 39.1% of lesions with initial scores were reclassified. G2 AKs had higher DEJ visibility than G3 both before and after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moisturization enhances LC\u2010OCT evaluation of hyperkeratotic AKs, improving DEJ visualization and diagnostic confidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70328","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:05:36Z","timestamp":1770815136000},"page":"1676-1680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing the Dermal Epidermal Junction of Hyperkeratotic Actinic Keratoses via Line\u2010Field Confocal Optical Coherence Tomography"],"prefix":"10.1111","volume":"65","author":[{"given":"Simone","family":"Michelini","sequence":"first","affiliation":[{"name":"Dermatology Clinic, 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