{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:45:19Z","timestamp":1783381519566,"version":"3.54.6"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autoimmune bullous diseases (AIBDs) constitute a rare yet potentially life\u2010threatening subset of immune\u2010related adverse events induced by immune checkpoint inhibitors (ICIs). However, the characteristics of ICI\u2010induced AIBDs (ICI\u2010AIBDs) and the factors influencing patient survival remain incompletely characterized. Therefore, we aimed to synthesize the available information on ICI\u2010AIBD patients and sought to explore factors potentially influencing the survival outcome of this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of 5 databases was conducted. Cox regression analysis was used to identify potential factors affecting patient survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Finally, a total of 188 studies with 319 participants were analyzed. The spectrum of AIBDs comprised bullous pemphigoid (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009254, 79.6%), lichen planus pemphigoides (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934, 10.7%), mucous membrane pemphigoid (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911, 3.4%), pemphigus group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097, 2.2%), linear IgA bullous dermatosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095, 1.6%), primarily induced by programmed cell death protein 1 inhibitors. In the exploratory analysis, female (hazard ratio [HR], 2.35; 95% confidence interval [CI], 1.10\u20135.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020) and pemphigus group (HR, 7.09; 95% CI, 1.87\u201326.96;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) were potentially associated with higher mortality, whereas topical glucocorticoid therapy was potentially protective (HR, 0.44; 95% CI, 0.21\u20130.93;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, we delineate the full clinical spectrum of ICI\u2010AIBDs, tentatively exploring factors potentially affecting patients' survival, which provides insights for individualized therapy and may inform future clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70362","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:14:03Z","timestamp":1772968443000},"page":"1420-1430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Autoimmune Bullous Diseases Associated With Immune Checkpoint Inhibitors: An Analysis Based on a Systematic Review"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7116-5152","authenticated-orcid":false,"given":"Min","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3486-8270","authenticated-orcid":false,"given":"Xun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyun","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7895-0115","authenticated-orcid":false,"given":"Jishu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mintong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyuan","family":"Li","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-9655","authenticated-orcid":false,"given":"Yue","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-6066","authenticated-orcid":false,"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-2884","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-025-01333-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.1624"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17850"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21836"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.70007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1071983"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.6665"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19860"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae172"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBISRIR-D-19-00099"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15248"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X21993279"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2022.0019"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/dermatopathology10030033"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14906"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.08.042"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16036"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.08.030"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000280"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1259071"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.691980"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13312"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.02.012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14601"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15405"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.02.025"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.008"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21653"},{"issue":"6","key":"e_1_2_10_30_1","article-title":"Linear IgA Bullous Dermatosis Associated With Immunotherapy","volume":"29","author":"Momin B.","year":"2023","journal-title":"Dermatology Online Journal"},{"issue":"3","key":"e_1_2_10_31_1","article-title":"Linear Immunoglobulin A Bullous Dermatosis Induced by Atezolizumab","volume":"16","author":"Almutairi S.","year":"2024","journal-title":"Dermatology Reports"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/skinhd\/vzae008"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.15161"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15203"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2024.103269"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12735"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13432"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15627"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13970"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2024.10.024"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3740"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11798"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-012-0981-9"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15638"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17253"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15644"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1478318"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00595-5"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19313"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.36823"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.10.013"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.12.075"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01290"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.70362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.70362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.70362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:04:39Z","timestamp":1780657479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.70362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/ijd.70362"],"URL":"https:\/\/doi.org\/10.1111\/ijd.70362","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,6]]},"assertion":[{"value":"2025-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}