{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:18:00Z","timestamp":1791839880029,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n CARD14\u2010associated papulosquamous eruption (CAPE) is a rare genetically mediated inflammatory skin disorder caused by gain\u2010of\u2010function variants in the\n CARD14<\/jats:italic>\n gene. It typically presents in infancy or early childhood with clinical features resembling both psoriasis and pityriasis rubra pilaris, and often exhibits a poor response to conventional therapies. An increasing number of studies support favorable outcomes with biologic medications, particularly interleukin (IL)\u201012\/23 and IL\u201017 inhibitors, for the treatment of CAPE. This literature review summarizes the etiology and pathophysiology of CAPE, with a focus on clinical features, genetic findings, and developments in treatment strategies.\n <\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>","DOI":"10.1111\/ijd.70387","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:12:50Z","timestamp":1773807170000},"page":"2049-2054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CARD14<\/scp>\n \u2010Associated Papulosquamous Eruption (\n CAPE<\/scp>\n ): An Updated Review of Pathogenesis and Treatment"],"prefix":"10.1111","volume":"65","author":[{"given":"Katherine","family":"Gavagan","sequence":"first","affiliation":[{"name":"Department of Dermatology Wayne State University School of Medicine Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6739-9701","authenticated-orcid":false,"given":"Aria","family":"Trager","sequence":"additional","affiliation":[{"name":"Michigan State University College of Osteopathic Medicine East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Esfandiari","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wayne State University School of Medicine Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Mehregan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wayne State University School of Medicine Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2022.100174"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14779"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.034"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14197"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2022-254090"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.09.002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.05.010"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17890"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16790"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14201"},{"issue":"6","key":"e_1_2_12_12_1","first-page":"e485","article-title":"Exploring Shared Clinical Features and Successful Therapeutic Interventions in CARD14\u2010Associated Papulosquamous Eruption","volume":"39","author":"Rossel S. 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