{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:15:54Z","timestamp":1789168554456,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Androgenetic alopecia (AGA) is the most common cause of hair loss in men. Although oral finasteride is effective, concerns about systemic adverse effects have increased interest in topical formulations. Long\u2010term real\u2010world data on topical finasteride monotherapy with objective trichoscopic evaluation are still limited.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective observational study evaluating the 52\u2010week effectiveness and safety of topical finasteride 0.25% monotherapy in adult men with AGA. Patients receiving other AGA treatments, hair transplantation, or with a history of sexual, mood\u2010related, or gynecomastia\u2010related disorders were excluded. Clinical and trichoscopic assessments at baseline and Week 52 (T52w) included target area hair count (TAHC), target area hair width (TAHW), and terminal\u2010to\u2010vellus hair ratio in vertex and frontotemporal regions. Patient\u2010reported outcomes were assessed using the Male Hair Growth Questionnaire (MHGQ), and physician evaluation through the Physician Global Assessment (PGA).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 146 men (mean age 31.1\u2009\u00b1\u20099.8\u2009years) were included. TAHC significantly increased at both the vertex (+\u200922.7 hairs\/cm\n 2<\/jats:sup>\n ) and frontotemporal regions (+\u200932.3 hairs\/cm\n 2<\/jats:sup>\n ) (\n p<\/jats:italic>\n \u2009<\u20090.001). TAHW and the ratio of terminal hair to vellus hair also improved significantly in both areas. Mean MHGQ score was 14.7\u2009\u00b1\u20092.9 and mean PGA was +\u20091.9\u2009\u00b1\u20090.8 at T52w. Mild, transient local irritation occurred in 6.2% of patients, with no systemic adverse effects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Topical finasteride 0.25% demonstrated sustained 52\u2010week effectiveness, particularly in the frontotemporal regions, with an excellent safety profile. These findings support topical finasteride as an effective long\u2010term treatment option for male AGA.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijd.70394","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:55:23Z","timestamp":1774356923000},"page":"2102-2107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and Safety of Topical Finasteride for Male Androgenetic Alopecia: Real World Data"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-9689","authenticated-orcid":false,"given":"Bianca Maria","family":"Piraccini","sequence":"first","affiliation":[{"name":"Private Dermatology Practice Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-941X","authenticated-orcid":false,"given":"Luca","family":"Rapparini","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2650-4616","authenticated-orcid":false,"given":"Federico","family":"Quadrelli","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2931-767X","authenticated-orcid":false,"given":"Francesca","family":"Pampaloni","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-7864","authenticated-orcid":false,"given":"Stephano","family":"Cedirian","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-425X","authenticated-orcid":false,"given":"Francesca","family":"Bruni","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-5443","authenticated-orcid":false,"given":"Matilde","family":"Iorizzo","sequence":"additional","affiliation":[{"name":"Private Dermatology Practice Lugano Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3981-1527","authenticated-orcid":false,"given":"Michela","family":"Starace","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S542000"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14624"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00730-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17738"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"457","article-title":"A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women","volume":"17","author":"Lee S. W.","year":"2018","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14895"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16360"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14387"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160551"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjv079"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17957"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.03.068"},{"issue":"12","key":"e_1_2_10_14_1","first-page":"51","article-title":"Persistent Sexual Dysfunction and Depression in Finasteride Users for Male Pattern Hair Loss: A Serious Concern or Red Herring?","volume":"7","author":"Singh M. K.","year":"2014","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"9","key":"e_1_2_10_15_1","article-title":"Topical Finasteride: A Comprehensive Review of Androgenetic Alopecia Management for Men and Women","volume":"15","author":"Keerti A.","year":"2023","journal-title":"Cureus"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.70394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.70394","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.70394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:54:01Z","timestamp":1789167241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.70394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ijd.70394"],"URL":"https:\/\/doi.org\/10.1111\/ijd.70394","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"2026-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}