{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:58:02Z","timestamp":1774846682453,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with substantial impairment in quality of life and psychological well\u2010being. The impact of cumulative treatment exposure and its relationship with multidimensional disease burden in HS has not been sufficiently discussed. The aim of this study is to investigate the associations between cumulative treatment burden, quality of life impairment, psychological symptom burden, disease activity, and patient\u2010perceived severity in patients with HS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter cross\u2010sectional study included previously treated adult HS patients. Participants completed validated Turkish versions of the Dermatology Life Quality Index (DLQI), Symptom Checklist\u201090\u2010Revised (SCL\u201090\u2010R), and the Hidradenitis Suppurativa Self\u2010Assessment Tool (HSSA). A Treatment Burden Index (TBI) was developed to quantify cumulative therapeutic exposure based on guideline\u2010weighted treatment modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010three patients were included (mean age 34.5\u2009\u00b1\u200911.0\u2009years; 57% male). Higher TBI was moderately correlated with greater QoL impairment (Spearman \u03c1\u2009=\u20090.401,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and flare frequency. TBI was weakly correlated with psychological symptom burden. DLQI scores were positively associated with flare frequency and SCL\u201090\u2010R scores, whereas the SCL\u201090\u2010R scores were not associated with flare frequency or patient\u2010perceived disease severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HS burden is multidimensional, with partially independent domains of disease activity, treatment burden, quality of life impairment, and psychological distress. Cumulative treatment exposure is closely linked to QoL impairment and disease activity but only weakly associated with psychological symptom burden. Identification of distinct burden phenotypes may facilitate more personalized and patient\u2010centered management strategies in HS.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/ijd70407-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70407","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T03:24:55Z","timestamp":1774841095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Treatment Burden With Quality of Life and Distress in Hidradenitis Suppurativa"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4211-2276","authenticated-orcid":false,"given":"Defne","family":"\u00d6zkoca","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology Ko\u00e7 University School of Medicine  \u0130stanbul Turkey"},{"name":"Dermatology Clinic Ba\u015fak\u015fehir \u00c7am Ve Sakura City Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut Gazi","family":"Erg\u00fcn","sequence":"additional","affiliation":[{"name":"Cerrahpa\u015fa Medical Faculty, Department of Dermatology and Venerology \u0130stanbul University\u2010Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilay Yerlio\u011flu","family":"Ak","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Ba\u015fak\u015fehir \u00c7am Ve Sakura City Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3857-0848","authenticated-orcid":false,"given":"Hediye","family":"Eker","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Ba\u015fak\u015fehir \u00c7am Ve Sakura City Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130rem","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Ko\u00e7 University School of Medicine  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Emre","family":"Bu\u011fday","sequence":"additional","affiliation":[{"name":"Intern Doctor Ko\u00e7 University School of Medicine  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-0215","authenticated-orcid":false,"given":"Didem \u015eenses","family":"Kazan","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Kartal Ac\u0131badem Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011fba","family":"Teh\u00e7i","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Adana City Hospital  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9521-0147","authenticated-orcid":false,"given":"Bengisu","family":"\u00d6zarslan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Ko\u00e7 University School of Medicine  \u0130stanbul Turkey"},{"name":"Mayo Clinic \u2013 Regenerative Dermatology &amp; 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