{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:15:26Z","timestamp":1789168526475,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Sentinel lymph node biopsy (SLNB) is one of the strongest prognostic indicators to date for cutaneous melanoma. However, its indication in elderly patients is controversial due to lower prognostic benefits, comorbidities, and surgical risks.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n The aim of this study was to develop and validate a predictive model specifically tailored to patients aged \u2265\u200975\u2009years with cutaneous melanoma, and to compare its performance with the Melanoma Institute Australia (MIA) and Memorial Sloan Kettering Cancer Center (MSKCC) calculators.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A multicenter, retrospective cohort study (SENTINOLD) including 795 patients aged \u2265\u200975\u2009years was conducted across seven Spanish hospitals, representing one of the largest European datasets of elderly melanoma patients. A multivariable logistic regression model was developed using 12 clinicopathologic variables. Model performance was assessed by discrimination (AUC), calibration, and decision curve analysis (DCA), and compared with MIA and MSKCC calculators. Temporal validation was performed using a hold\u2010out dataset representing the most recent diagnoses.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The SENTINOLD nomogram demonstrated robust discrimination (AUC\u2009=\u20090.71), outperforming the MSKCC (0.66) and MIA (0.64) models (\n p<\/jats:italic>\n \u2009<\u20090.05). Calibration and decision curve analysis confirmed greater clinical usefulness within the 5%\u201320% decision threshold range. Temporal validation showed stable performance (AUC\u2009=\u20090.68; Brier\u2009=\u20090.187). An interactive web\u2010based calculator is freely available at\n https:\/\/sentinold.netlify.app<\/jats:ext-link>\n , allowing clinicians to estimate the risk of SLN positivity using key tumor and patient characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The SENTINOLD nomogram provides a reliable, user\u2010friendly, and population\u2010specific tool for individualized prediction of sentinel lymph node positivity in elderly melanoma patients. Its use may assist clinicians in guiding SLNB decision\u2010making in this age group, although independent external validation and prospective evaluation of clinical impact are warranted.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijd.70413","type":"journal-article","created":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T15:40:21Z","timestamp":1776008421000},"page":"2108-2116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improving Risk Stratification for SLNB in Elderly Patients With Melanoma: The SENTINOLD Nomogram"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-2970","authenticated-orcid":false,"given":"Nieves","family":"Mart\u00ednez Campayo","sequence":"first","affiliation":[{"name":"Dermatology Department Complejo Hospitalario Universitario de A Coru\u00f1a A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-6459","authenticated-orcid":false,"given":"Sabela","family":"Paradela de la Morena","sequence":"additional","affiliation":[{"name":"Dermatology Department Complejo Hospitalario Universitario de A Coru\u00f1a A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-0522","authenticated-orcid":false,"given":"Sebastian","family":"Podlipnik","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Cl\u00ednic, IDIBAPS, University of Barcelona\/CIBERER Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-9745","authenticated-orcid":false,"given":"Susana","family":"Puig","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Cl\u00ednic, IDIBAPS, University of Barcelona\/CIBERER Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6998-914X","authenticated-orcid":false,"given":"Josep","family":"Malvehy","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Cl\u00ednic, IDIBAPS, University of Barcelona\/CIBERER Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-8820","authenticated-orcid":false,"given":"Cristina","family":"Carrera","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Cl\u00ednic, IDIBAPS, University of Barcelona\/CIBERER Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-8707","authenticated-orcid":false,"given":"Eduardo","family":"Nagore","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Valenciano de Oncolog\u00eda (IVO) Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-4998","authenticated-orcid":false,"given":"Ruggero","family":"Moro","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Valenciano de Oncolog\u00eda (IVO) Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-5308","authenticated-orcid":false,"given":"Aram","family":"Boada","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitari Germans Trias i Pujol\/Institut D'investigaci\u00f3 Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-8769","authenticated-orcid":false,"given":"Nina","family":"Richarz","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital 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