{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:07:52Z","timestamp":1779196072401,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82505675"],"award-info":[{"award-number":["82505675"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The transient receptor potential vanilloid 1 (TRPV1) channel is a critical mediator in pruritus signaling, and its antagonists represent a promising therapeutic strategy to disrupt the \u201citch\u2010scratch\u201d cycle in atopic dermatitis (AD). This meta\u2010analysis was conducted to evaluate the efficacy and safety of TRPV1 antagonists for AD, with available evidence focusing on the topical agent asivatrep. A systematic search was performed across seven databases (e.g., CENTRAL, Embase, and MEDLINE) from inception to December 27, 2025, without language restrictions. With study selection, data extraction, and risk\u2010of\u2010bias assessment completed independently by two investigators, a random\u2010effects model was applied for meta\u2010analysis. Although our search strategy was designed to capture all TRPV1 antagonists, only two randomized controlled trials (RCTs,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009431) met the inclusion criteria, both evaluating the topical, highly selective TRPV1 antagonist asivatrep (PAC\u201014028) 1.0% cream. Compared with the vehicle control, asivatrep significantly improved physician\u2010assessed skin lesions (e.g., Investigator's Global Assessment 0\/1 response: risk ratio [RR] 3.23, 95% confidence interval [CI] 2.02 to 5.17; Eczema Area and Severity Index (EASI)\u201075 response: RR 1.84, 95% CI 1.18 to 2.87) and significantly alleviated patient\u2010reported pruritus and sleep disturbance. The incidence of all adverse events (RR 1.41, 95% CI 0.53 to 3.76) and drug\u2010related adverse events (RR 0.64, 95% CI 0.08 to 4.97) in the Asivatrep 1.0% group did not differ significantly from the vehicle group. In conclusion, topical asivatrep (1.0% cream) effectively and safely improves lesion severity and pruritus in patients with mild\u2010to\u2010moderate AD. However, as current evidence is confined to asivatrep in mild\u2010to\u2010moderate AD, a class effect for TRPV1 antagonists cannot be established.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/ijd70469-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/ijd.70469","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:21:39Z","timestamp":1779193299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of\n                    <scp>TRPV1<\/scp>\n                    Antagonists for Atopic Dermatitis: A Systematic Review and Meta\u2010Analysis Focusing on Asivatrep"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-7323","authenticated-orcid":false,"given":"Jindong","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital, Fudan University  Shanghai China"},{"name":"Department of Integrative Medicine, Baoshan Campus of Huashan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Center &amp; National Clinical Research Center for Aging and Medicine, Jing'an District Central Hospital of Shanghai Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4663-555X","authenticated-orcid":false,"given":"Lingwen","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7710-7792","authenticated-orcid":false,"given":"Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Center &amp; National Clinical Research Center for Aging and Medicine, Jing'an District Central Hospital of Shanghai Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-968X","authenticated-orcid":false,"given":"Xiaohong","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100001\u2010z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(24)02519\u20104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.07.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19580"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14891"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2011.10449.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.023"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15973"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.02.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.09.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906\u20106705.2004.0178.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.4643\u201006.2007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.048"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16121707"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.627985"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.09.002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010015\u20108488\u20105"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.023"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17777"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.87"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17455"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.09.024"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_10_25_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgins J. 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