{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:54:36Z","timestamp":1791438876157,"version":"4.3.3"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Further studies are required to support the clinical value of paraffin\u2010embedded microscopically controlled surgery (MCS) in lentigo maligna (LM) and lentigo maligna melanoma (LMM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective observational study to review histologically confirmed LM and LMM cases treated definitively and exclusively with paraffin\u2010embedded MCS, specifically, staged excision, with at least \u2265\u20096\u2009months follow\u2010up if recurrence was absent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and ninety\u2010four patients were eligible for inclusion, with a median age of 72.5\u2009years. Most cases were primary tumors (82%). Tumors were predominantly located on the face (167, 86.1%), especially on the cheek (73, 37.6%). Most of the cases were LM (141, 72.7%). LMMs had a median Breslow thickness of 0.48\u2009mm and were mainly T1a (38, 71.7%) (8th edition of the AJCC staging system). Dermoscopy was routinely utilized to delineate the tumor border prior to surgery, and in 29 cases (15.0%), Wood's lamp was also employed. All patients achieved negative margins with paraffin\u2010embedded MCS. After a global median follow\u2010up of 34\u2009months, seven patients (3.6%) had LR. LRR was higher in LMM (4\/53, 7.5%) than LM (3\/141, 2.1%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09). The restricted mean survival time (RMST) at 36\u2009months was 36.0\u2009months for LM and 34.9\u2009months for LMM. LMM patients tended to have LR earlier\u2014on average, 1.1\u2009months sooner in the first 36\u2009months than LM patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.13). Given the low number of events (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097), multivariable survival modeling was not used to prevent unstable or overfitted estimates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Paraffin\u2010embedded MCS provides accurate margin control and low LRR for LM and LMM.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/ijd70475-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70475","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:19:56Z","timestamp":1778822396000},"page":"2343-2351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lentigo Maligna Treated With Microscopically Controlled Surgery: A 194\u2010Patient Retrospective Study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-2750","authenticated-orcid":false,"given":"Gloria","family":"Baeza\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Dermatology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"},{"name":"Dermatology Department Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Dermatology Department Complejo Asistencial de Segovia  Segovia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-4998","authenticated-orcid":false,"given":"Ruggero","family":"Moro","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"},{"name":"Doctorate School Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-4169","authenticated-orcid":false,"given":"Celia","family":"Requena","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Traves","sequence":"additional","affiliation":[{"name":"Pathology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-8707","authenticated-orcid":false,"given":"Eduardo","family":"Nagore","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"},{"name":"School of Medicine Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13092527"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2023.04.023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1690624"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2019.09.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2024.02.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.01.051"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.063"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18880"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7898"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae364"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.06.059"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae422"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.04.090"},{"issue":"6","key":"e_1_2_9_15_1","first-page":"25","article-title":"Staged Excision for Lentigo Maligna and Lentigo Maligna Melanoma: Analysis of Surgical Margins and Long\u2010Term Recurrence in 68 Cases From a Single Practice","volume":"9","author":"Wilson J. 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