{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:54:08Z","timestamp":1792176848024,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis (PSO) and atopic dermatitis (AD) have long been regarded as distinct entities. However, emerging evidence indicates that they may represent two poles of a shared immunologic spectrum, where Th1\/Th17 and Th2 pathways coexist or shift dynamically. The clinical overlap between these diseases, whether spontaneous or biologic\u2010induced, remains poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective bicentric study (February 2023\u2013June 2025) at two Italian tertiary centers. Clinical, dermatopathological, and photographic databases were screened with predefined terms. Descriptive analyses summarized characteristics and treatment responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 105 patients: 49 with spontaneous (20 coexisting; 29 overlapping) and 56 with drug\u2010induced conditions (31 anti\u2010IL\u201017\u2010 and 6 anti\u2010TNF\u03b1\u2010drug induced eczema; 19 dupilumab\u2010induced PSO). Coexisting cases often combined scalp\/elbow PSO with palmoplantar or flexural eczema. Overlapping lesions, frequently on hands\/soles, showed mixed histology (spongiosis with acanthosis, hypogranulosis, and Munro microabscesses). For spontaneous forms, Janus kinase (JAK) inhibitors were the most consistently effective treatment, followed by IL\u201023 inhibitors and methotrexate. After withdrawal of culprit biologics, JAK inhibitors and anti IL\u201023 agents achieved high control rates of drug\u2010induced eczemas. Dupilumab\u2010induced PSO was mainly in plaques or palmoplantar; about half of the cases were manageable without drug discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PSO and AD may represent a continuum spectrum of disease with coexisting or overlapping presentations that influence treatment choices; forms of psoriasis or eczema induced by biological drugs also complicate diagnosis and treatment. JAK inhibitors, targeting shared downstream signaling, represent a rational, effective option at the PSO\u2013AD interface.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/ijd70484-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70484","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T15:00:37Z","timestamp":1779462037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Psoriasis\u2013Eczema Interface: Clinical Classification and Therapeutic Implications From a Bicentric Experience"],"prefix":"10.1111","author":[{"given":"Michela","family":"D'Agostino","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1219-9008","authenticated-orcid":false,"given":"Gennaro Marco","family":"Falco","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. 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Gemelli IRCCS  Rome Italy"},{"name":"Pathology Unit, Department of Woman and Child's Health and Public Health Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3309-8190","authenticated-orcid":false,"given":"Maddalena","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-6600","authenticated-orcid":false,"given":"Ketty","family":"Peris","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. 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