{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T14:05:44Z","timestamp":1779545144057,"version":"3.53.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574007"],"award-info":[{"award-number":["82574007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although alopecia areata (AA) typically presents as focal patches, it may manifest as hairline alopecia. We previously described an unusual AA presentation characterized by frontotemporal hairline recession with isolated single hairs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010six patients with frontotemporal hairline recession and isolated single hairs were prospectively enrolled. Clinical, trichoscopic, and histopathologic features were characterized. Treatment outcomes were described by Severity of Alopecia Tool (SALT) score changes at months 3 and 6 and categorical status at last follow\u2010up; 3\u2009month corticosteroid response was compared with matched patchy AA controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients (62.5% female; mean age 30.4\u2009years) had a mean disease duration of 6.5\u2009years and a mean baseline SALT score of 29.0. More than half had prior patchy AA. Trichoscopy consistently showed a predominance of 1\u2010hair follicular units at the hairline. In biopsied cases, histopathology showed preserved pilosebaceous units, markedly increased telogen follicles, and residual solitary terminal hairs, without perifollicular fibrosis or lichenoid inflammation. Among 30 patients with evaluable outcomes, the median percent change in SALT score was 0% at Month 3 and 18.4% at Month 6. At the last evaluable follow\u2010up, 6 patients (20.0%) achieved significant improvement. In the matched analysis, this phenotype showed a lower 3\u2009month SALT\n                      <jats:sub>50<\/jats:sub>\n                      response to systemic corticosteroids than patchy AA (5.9% vs. 76.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This expanded cohort characterizes a frontal fibrosing alopecia (FFA)\u2010like phenotype within the AA spectrum, supported by a non\u2010scarring histopathologic profile in biopsied cases. Follow\u2010up data suggest an insidious, chronic course and limited scalp hair regrowth among treated patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70493","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:04:34Z","timestamp":1779512674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alopecia Areata With an\n                    <scp>FFA<\/scp>\n                    \u2010Like Phenotype: Clinicopathologic Features and Treatment Outcomes in a Prospective Cohort"],"prefix":"10.1111","author":[{"given":"Xiaolin","family":"Zhang","sequence":"first","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Qiao","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebao","family":"Shao","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofan","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4721-7728","authenticated-orcid":false,"given":"Jiaping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8507-9358","authenticated-orcid":false,"given":"Suzheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00664-9"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17780"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08883-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.10.126"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.261"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.1736"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2006.00227.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01238.x"},{"issue":"2","key":"e_1_2_12_10_1","article-title":"Alopecia Areata Mimicking Frontal Fibrosing Alopecia","volume":"13","author":"Trindade de Carvalho L.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16105"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14283"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1995.46"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb02825.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16313"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144121"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-024-00912-w"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15775"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.032"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2026.02.068"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00479-x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00959-8"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.05.008"},{"issue":"1","key":"e_1_2_12_25_1","first-page":"41","article-title":"Comparison of the Treatment Outcome of Oral Tofacitinib With Other Conventional Therapies in Refractory Alopecia Totalis and Universalis: A Retrospective Study","volume":"99","author":"Shin J. W.","year":"2019","journal-title":"Acta Dermato\u2010Venereologica"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.70493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.70493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.70493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:22:09Z","timestamp":1779542529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.70493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":24,"alternative-id":["10.1111\/ijd.70493"],"URL":"https:\/\/doi.org\/10.1111\/ijd.70493","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]},"assertion":[{"value":"2026-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ijd.70493"}}