{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:00:29Z","timestamp":1790312429791,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Head\u2013neck atopic dermatitis (HND) represents a clinically challenging phenotype of atopic dermatitis (AD). Currently, real\u2010world evidence on lebrikizumab specifically focusing on patients with head\u2013neck involvement remains limited, as well as data on flare occurrence and management during treatment with this biologic drug. This real\u2010life study aimed to evaluate the effectiveness of lebrikizumab in patients with HND, with particular attention to flare occurrence and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter retrospective observational study was conducted enrolling patients with AD involving the head\u2013neck region treated with lebrikizumab and with at least one follow\u2010up visit. The primary endpoint was the change in head\u2013neck Eczema Area and Severity Index (EASI\u2010HN) from baseline to Week (W) 16. Secondary outcomes included changes in total EASI, pruritus Numerical Rating Scale (P\u2010NRS), Dermatology Life Quality Index (DLQI), EASI75\/EASI90 response rates, and head\u2013neck flare occurrence during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 197 patients were included. Median baseline total EASI and EASI\u2010HN were 20.0 (interquartile range [IQR] 8.0\u201325.0) and 3.0 (IQR 2.0\u20134.0), respectively. Among patients with paired W16 data (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009118), median EASI\u2010HN decreased from 2.8 to 1.0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while total EASI decreased from 20.0 to 3.0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Significant improvements were also observed in P\u2010NRS and DLQI. Among patients with available W52 data (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953), EASI75 and EASI90 were achieved by 69.8% and 62.3%, respectively. Overall, 39\/197 patients (19.8%) experienced at least one documented head\u2013neck flare during follow\u2010up, whereas 54\/197 (27.4%) experienced at least one flare\u2010related event, defined as a documented flare and\/or rescue therapy use. Most patients experiencing flare\u2010related events were managed with topical therapies, and no treatment discontinuations occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Lebrikizumab demonstrated rapid and sustained effectiveness in patients with HND, with marked improvements in disease severity, pruritus, and quality of life. Head\u2013neck flares were relatively uncommon and generally manageable with topical therapies.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/ijd70704-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.70704","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:35:32Z","timestamp":1790310932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Effectiveness of Lebrikizumab in Patients With Head\u2013Neck Atopic Dermatitis: A Multicenter Study With Focus on Flare Occurrence"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4132-6312","authenticated-orcid":false,"given":"Marika","family":"Del Gaudio","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-0592","authenticated-orcid":false,"given":"Luca","family":"Potestio","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-1366","authenticated-orcid":false,"given":"Silvia Mariel","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan 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