{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:45:14Z","timestamp":1792053914736,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Female pattern hair loss (FPHL), characterized by progressive follicular miniaturization, is the most common cause of hair thinning in women and increases in prevalence after menopause. While topical minoxidil is approved for FPHL, clinical response is variable. Oral finasteride is used off label in postmenopausal women but raises concerns regarding systemic adverse effects. Topical finasteride may represent an alternative with reduced systemic exposure.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective observational study was conducted in 26 postmenopausal women with FPHL who were treated with topical finasteride 0.25% monotherapy for 52\u2009weeks. Clinical and trichoscopic images obtained at baseline and Week 52 were used to assess changes in hair density, hair thickness, and the terminal\u2010to\u2010vellus hair ratio in predefined target areas in frontal or vertex regions. Patient\u2010reported tolerability and compliance, as well as patient\u2010 and clinician\u2010reported effectiveness, were assessed using 3\u2010point ordinal scales.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean hair density increased from 149.48\u2009\u00b1\u200934.32 to 172.84\u2009\u00b1\u200935.29 hairs\/cm\n 2<\/jats:sup>\n (\n p<\/jats:italic>\n \u2009<\u20090.001). Hair thickness increased from 40.42\u2009\u00b1\u20097.15\u2009\u03bcm to 51.04\u2009\u00b1\u20099.28\u2009\u03bcm (\n p<\/jats:italic>\n \u2009<\u20090.001), and terminal\u2010to\u2010vellus hair ratio increased from 1.04\u2009\u00b1\u20090.61 to 1.56\u2009\u00b1\u20090.64 (\n p<\/jats:italic>\n \u2009<\u20090.001). Subjective patient and clinician assessments indicated good\u2010to\u2010excellent effectiveness. No adverse events were recorded; tolerability and compliance were rated highly by patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Topical finasteride 0.25% monotherapy was associated with significant improvements in hair density and thickness, alongside favorable reported tolerability and compliance. These findings provide preliminary real\u2010world observational data regarding topical finasteride use in the underserved population of postmenopausal women with FPHL.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijd.70730","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:00:32Z","timestamp":1792051232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical Finasteride 0.25% Solution for Female Pattern Hair Loss (FPHL) in Postmenopausal Women: A 52\u2010Week Retrospective Observational Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-9689","authenticated-orcid":false,"given":"Bianca Maria","family":"Piraccini","sequence":"first","affiliation":[{"name":"Private Dermatology Practice Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Temerty Faculty of Medicine University of Toronto Toronto Canada"},{"name":"Mediprobe Research Inc. London Ontario Canada"},{"name":"Division of Dermatology, Department of Medicine Women's College Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-7864","authenticated-orcid":false,"given":"Stephano","family":"Cedirian","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-941X","authenticated-orcid":false,"given":"Luca","family":"Rapparini","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2650-4616","authenticated-orcid":false,"given":"Federico","family":"Quadrelli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4989-9807","authenticated-orcid":false,"given":"Shannon A. H.","family":"Compton","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc. London Ontario Canada"},{"name":"University of Western Ontario London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0691-640X","authenticated-orcid":false,"given":"Mesbah","family":"Talukder","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc. London Ontario Canada"},{"name":"School of Pharmacy BRAC University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3981-1527","authenticated-orcid":false,"given":"Michela","family":"Starace","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2018.05.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806\u20104841.20153370"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01528"},{"key":"e_1_2_10_5_1","volume-title":"StatPearls","author":"Ho C. 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