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This study was carried out to evaluate the safety of green cocoa tea water extract (<jats:styled-content style=\"fixed-case\">CWE<\/jats:styled-content>) by determining its potential toxicity after subacute administration in <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> rats. In the subacute toxicity study, oral administration of <jats:styled-content style=\"fixed-case\">CWE<\/jats:styled-content> up to 800\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> body weight\u00a0day<jats:sup>\u22121<\/jats:sup> for twenty\u2010eight consecutive days did not cause either mortality or toxicity in <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca<jats:sup>2+<\/jats:sup>, total Ca) in <jats:styled-content style=\"fixed-case\">CWE<\/jats:styled-content>\u2010treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup> was identified as the no observed adverse effect level (<jats:styled-content style=\"fixed-case\">NOAEL<\/jats:styled-content>) in this study.<\/jats:p>","DOI":"10.1111\/ijfs.12905","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T05:41:31Z","timestamp":1438321291000},"page":"2391-2401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Subacute oral toxicity of cocoa tea (<i>Camellia ptilophylla<\/i>) water extract in <scp>SD<\/scp> rats"],"prefix":"10.1093","volume":"50","author":[{"given":"Kaikai","family":"Li","sequence":"first","affiliation":[{"name":"School of Life Sciences Sun Yat\u2010sen University Guangzhou 510275 China"},{"name":"Institute of Chinese Medicine The Chinese University of Hong Kong Shatin New Territories Hong Kong SAR 999077 China"},{"name":"State Key Laboratory 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