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Several cytokine genes may play crucial roles in host susceptibility to<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, because the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphisms. The association of the interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20102 gene polymorphisms with the susceptibility to<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>was investigated in this study.<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>samples were obtained from a Turkish population of 97 patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>and 76 healthy control subjects. Polymorphisms of<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 gene at position \u2212330 and +166 were determined using the polymerase chain reaction with sequence\u2010specific primers. In the patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, there was a significantly increased frequency of<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 \u2212330<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>genotype. Interestingly, we demonstrated that the frequencies of<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 \u2212330<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102\u00a0+\u00a0166<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>genotypes were increased in<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>patients with ocular involvement, whilst<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 \u2212330<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>genotype was significantly decreased. Also, analysis of allele frequency demonstrated that the presence of G allele at position +166 of<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 seems to be a risk factor for ocular involvement. These results reveal that<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 \u2212330<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>genotype may be a susceptibility factor for<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, whereas<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 \u2212330<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>genotype seems to display a protective association with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. Additionally,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 gene polymorphisms might be associated with ocular involvement in<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/iji.12039","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T12:08:58Z","timestamp":1358770138000},"page":"349-355","source":"Crossref","is-referenced-by-count":6,"title":["Interleukin\u20102 gene polymorphism in<scp>T<\/scp>urkish patients with<scp>B<\/scp>eh\u00e7et's disease and its association with ocular involvement"],"prefix":"10.1111","volume":"40","author":[{"given":"A.","family":"Y\u00fccel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Uludag University Faculty of Medicine Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Dilek","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Uludag University Faculty of Medicine Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Uludag University Faculty of Medicine Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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