{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:04:46Z","timestamp":1761581086210},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,7]],"date-time":"2013-04-07T00:00:00Z","timestamp":1365292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Summary<\/jats:title>This study was designed to determine the possible asssociation between selected FAS<\/jats:styled-content><\/jats:italic> and FASLG<\/jats:styled-content><\/jats:italic> polymorphisms and Hepatitis B virus (HBV<\/jats:styled-content>) infection. FAS<\/jats:styled-content><\/jats:italic>\u2010670 G\/A, FAS<\/jats:styled-content><\/jats:italic>\u20101377 G\/A, FASLG<\/jats:styled-content><\/jats:italic>\u2010844 T\/C and FASLG<\/jats:styled-content><\/jats:italic> IVS<\/jats:styled-content>2nt\u2010124 A\/G polymorphisms were genotyped by polymerase chain reaction and restriction fragment length polymorphism (PCR<\/jats:styled-content>\u2010RFLP<\/jats:styled-content>). A total of age and sex matched 108 controls and a hundred chronic HBV<\/jats:styled-content> patients were recruited to conduct a case\u2013control study. FAS<\/jats:styled-content><\/jats:italic>\u2010670 polymorphism was associated with chronic HBV<\/jats:styled-content> infection (P<\/jats:italic>\u00a0=\u00a00.03) FAS<\/jats:styled-content>\u2010<\/jats:italic>1377 GG<\/jats:styled-content>, GA<\/jats:styled-content> and AA<\/jats:styled-content> genotypes among the cases (90%, 5% and 5%, respectively) were significantly different from those among the controls (68%, 31.5% and 5.6%; P<\/jats:italic>\u00a0=\u00a00.00). FASLG<\/jats:styled-content><\/jats:italic>\u2010844 allele distribution was similar between the groups (P<\/jats:italic>\u00a0=\u00a00.17) but TC<\/jats:styled-content> genotype (67.3%) was frequent in chronic HBV<\/jats:styled-content> patients, while CC<\/jats:styled-content> genotype was found significantly higher (29.6%) in controls. No association between FASLG<\/jats:styled-content><\/jats:italic> IVS<\/jats:styled-content>2nt\u2010124 polymorphism and chronic HBV<\/jats:styled-content> infection could be identified (P<\/jats:italic>\u00a0=\u00a00.55). FAS<\/jats:styled-content><\/jats:italic>\u2010670 polymorphism is associated with chronic HBV<\/jats:styled-content> infection, while FASLG<\/jats:styled-content><\/jats:italic> IVS<\/jats:styled-content>2nt\u2010124 A\/G polymorphism is not. The FAS<\/jats:styled-content><\/jats:italic>\u20101377G\/A and FASLG<\/jats:styled-content>\u2010<\/jats:italic>844 T\/C genotypes are likely to play a substantial role in HBV<\/jats:styled-content> infection. Further studies evaluating polymorphisms in other genes related with apoptosis are needed to elucidate the role of genetic variation in HBV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iji.12056","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T01:48:47Z","timestamp":1365385727000},"page":"482-487","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of death pathway genes FAS<\/scp><\/i> and FASL<\/scp><\/i> polymorphisms in chronic HBV<\/scp> infection"],"prefix":"10.1111","volume":"40","author":[{"given":"A. G.","family":"Zamani","sequence":"first","affiliation":[{"name":"Medical Genetics Meram Medical Faculty Konya University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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