{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:36:06Z","timestamp":1776173766559,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T00:00:00Z","timestamp":1365379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Several pieces of evidence support the involvement of immune system in <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eni\u00e8re's disease (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>). Macrophage migration inhibitory factor (<jats:styled-content style=\"fixed-case\">MIF<\/jats:styled-content>) plays a key role in immune\u2010mediated reactions. Several studies have shown an association between <jats:styled-content style=\"fixed-case\">MIF<\/jats:styled-content> gene polymorphisms and susceptibility to various inflammatory and autoimmune disorders. The aim of this study was to explore the association between <jats:styled-content style=\"fixed-case\">MIF<\/jats:styled-content>\u2010173 G\/C polymorphism and <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> in an <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ranian population. In this case\u2013control association study, <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> cases (<jats:italic>N<\/jats:italic>\u00a0=\u00a072) were recruited and were comprised of definitive <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> (<jats:italic>N<\/jats:italic>\u00a0=\u00a058) and probable <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> (<jats:italic>N<\/jats:italic>\u00a0=\u00a014) subjects. Normal healthy subjects (<jats:italic>N<\/jats:italic>\u00a0=\u00a0100) were also included. Genotyping for <jats:styled-content style=\"fixed-case\">MIF<\/jats:styled-content>\u2010173 G\/C polymorphism was carried out using <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> technique. There was a significant increase in genotype <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> compared with the control group. (<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00.02, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.08, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.02\u20134.3). This was more significant when definitive <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> was stratified and compared with the controls (<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00.009, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.19\u20136.18). This study's result indicates the potential role of <jats:styled-content style=\"fixed-case\">MIF<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> of which further evaluation is required. Also, the more significant association between <jats:styled-content style=\"fixed-case\">MIF<\/jats:styled-content> gene polymorphism and definitive <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> designates the involvement of specific pathogenic mechanisms which may be considered as a marker for diagnosis.<\/jats:p>","DOI":"10.1111\/iji.12058","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T02:14:45Z","timestamp":1365473685000},"page":"488-491","source":"Crossref","is-referenced-by-count":19,"title":["Association between <scp>MIF<\/scp> gene variation and <scp>M<\/scp>eniere's disease"],"prefix":"10.1111","volume":"40","author":[{"given":"N.","family":"Yazdani","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Research Center, Amir\u2010Alam Hospital Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. T.","family":"Khorsandi Ashtiani","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, Amir\u2010Alam Hospital Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Zarandy","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, Amir\u2010Alam Hospital Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, Amir\u2010Alam Hospital Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ghazavi","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, Amir\u2010Alam Hospital Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mahrampour","sequence":"additional","affiliation":[{"name":"Endocrinology and metabolism research centre Tehran University of medical sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Amiri","sequence":"additional","affiliation":[{"name":"Endocrinology and metabolism research centre Tehran University of medical sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Amoli","sequence":"additional","affiliation":[{"name":"Endocrinology and metabolism research centre Tehran University of medical sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease","volume":"113","author":"American Academy of Otolaryngology\u2010Head and Neck Surgery Committee on Hearing and Equilibrium","year":"1995","journal-title":"Otolaryngology and head and neck surgery"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001003800108"},{"key":"e_1_2_5_4_1","first-page":"1671","article-title":"Macrophage migration inhibitory factor gene polymorphism is associated with sarcoidosis in biopsy proven erythema nodosum","volume":"29","author":"Amoli M.M.","year":"2002","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363867"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780050060010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.6.1895"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200108)44:8<1782::AID-ART314>3.0.CO;2-#"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10492"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23314.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.10.010"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.01.004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728220903551304"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2003.610112.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489209137456"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00018-X"},{"key":"e_1_2_5_17_1","first-page":"35","article-title":"On genetic and environmental factors in Meniere's disease","volume":"15","author":"Morrison A.W.","year":"1994","journal-title":"American Journal of Otology"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21285"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/432009"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000136101.95662.aa"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364310"},{"key":"e_1_2_5_22_1","first-page":"526","article-title":"The pathophysiology of Meniere's disease","volume":"5","author":"Schuknecht H.F.","year":"1984","journal-title":"American Journal of Otology"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.05.003"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016480802631966"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67144-9"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22179"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100098698"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12058","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:32:42Z","timestamp":1696231962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,8]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/iji.12058"],"URL":"https:\/\/doi.org\/10.1111\/iji.12058","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,8]]}}}