{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:52:31Z","timestamp":1771962751866,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of the study was to examine the relation between polymorphisms and serum levels of selected cytokines (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015), production of autoantibodies and factors describing rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>), such as <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 and Total Sharp Score. A total of 156 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> according to the <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> criteria, and 200 control subjects were recruited into the study. The measurements of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>, the presence of rheumatoid factors (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>s), radiographs of both hands with calculation of Total Sharp Score (<jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 were obtained from all patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. In total, five polymorphisms in genes coding cytokines (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015) were detected. The levels of these selected cytokines were measured in serum using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> method. A significant difference in allele frequencies between patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and controls was observed for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 \u2010267C\/T polymorphism. A higher prevalence of heterozygote variants of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 polymorphisms (14035A\/T and \u2010267C\/T) in the <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> IgG\u2013 and RF IgA\u2013negative subgroups was observed. Furthermore, the association of polymorphisms in gene for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 with circulating level of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 (14035A\/T and 367G\/A) and with total <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> and Ig\u2010specific RFs (\u2010267C\/T) was found. The relation of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 to <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>s IgA, IgM, IgG and the measure of <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 was proved. The frequency of the T allele of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 polymorphism \u20101112C\/T was higher in subgroup with faster progression of the disease (<jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content>\/month \u2265 0.1). In conclusion, we present an association of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 gene polymorphisms with the RFs including subtypes (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>, IgG, IgA) underlined by the relation of increased <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015 levels in circulation to <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/iji.12065","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T09:08:55Z","timestamp":1371460135000},"page":"34-40","source":"Crossref","is-referenced-by-count":22,"title":["Relation of IL\u20106, IL\u201013 and IL\u201015 gene polymorphisms to the rheumatoid factors, anti\u2010CCP and other measures of rheumatoid arthritis activity"],"prefix":"10.1111","volume":"41","author":[{"given":"M.","family":"Pavkova Goldbergova","sequence":"first","affiliation":[{"name":"Institute of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Nemec","sequence":"additional","affiliation":[{"name":"Rheumatology Division St. Anne's University Hospital Brno Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lipkova","sequence":"additional","affiliation":[{"name":"Institute of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jarkovsky","sequence":"additional","affiliation":[{"name":"Institute of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech 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