{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:11:54Z","timestamp":1696399914620},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Leprosy is one of the most neglected infectious tropical diseases of the skin and the nerves caused by the intracellular pathogen <jats:italic>Mycobacterium leprae<\/jats:italic>. The inducible <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> isoform encoded by <jats:italic><jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>2A<\/jats:italic> plays a vital role in host defence against bacterial infections. The functional promoter polymorphisms in <jats:italic><jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>2A<\/jats:italic> are associated with various autoimmune and infectious diseases. We investigated the association of <jats:italic><jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>2A<\/jats:italic> variants with progression of leprosy in a Brazilian cohort including 221 clinically classified patients and 103 unrelated healthy controls. We observed a novel variant ss528838018A\/G in the promoter region at position \u22126558. The other functional variants were observed with low frequency of minor allele (&lt;0.005). <jats:italic><jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>2A<\/jats:italic> promoter variant (\u2212954G\/C) was not observed in Brazilian populations, and the new observed promoter variant (ss528838018A\/G) as well as other promoter variants were not associated with any clinical forms of leprosy in the Brazilian populations.<\/jats:p>","DOI":"10.1111\/iji.12108","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T12:05:17Z","timestamp":1391601917000},"page":"231-235","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene in Brazilian patients with leprosy"],"prefix":"10.1111","volume":"41","author":[{"given":"I. J. 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