{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:33:15Z","timestamp":1755693195405},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo de Investigaciones Sanitarias (Ministry of Health, Spain)","award":["FIS 06\/801 and FIS 10\/2626"],"award-info":[{"award-number":["FIS 06\/801 and FIS 10\/2626"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mannose\u2010binding lectin (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>) is a serum protein that activates the complement and mediates phagocytosis. <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> levels and <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2 genotype may impact upon host susceptibility to tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) disease but evidence to date has been conflicting. <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2 exon 1 and promoter genotyping and serum MBL concentrations were determined in 79 patients with active tuberculosis (58 pulmonary TB and 21 extrapulmonary or miliary TB) and 120 household healthy contacts (HHC) from a Mediterranean area (Majorca Island, Spain). Significantly higher serum MBL levels were found in patients with active tuberculosis than in HHC [median MBL concentrations 3430\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup> (10\u201328\u00a0415) and 2600\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup> (5\u201320\u00a0000) respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002]. These higher MBL levels were mainly related to the most prevalent YA\/YA wild\u2010type diplotype. There was a strong correlation between MBL2 exon 1 and promoter genotype and MBL levels. The diplotype LYQA\/HYPA was present in 12 out of 57 of the pulmonary TB cases but in none of the extrapulmonary TB patients. Diplotype LXPA\/HYPA, producer of high levels of MBL, was significantly more frequent in HHC than in patients (16.8% vs. 6.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.031) suggesting a protective role against the development of TB disease that has not been previously found.<\/jats:p>","DOI":"10.1111\/iji.12126","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T10:57:48Z","timestamp":1402311468000},"page":"306-311","source":"Crossref","is-referenced-by-count":11,"title":["Mannose\u2010binding lectin exon 1 and promoter polymorphisms in tuberculosis disease in a mediterranean area"],"prefix":"10.1111","volume":"41","author":[{"given":"M.","family":"Garc\u00eda\u2010Gasalla","sequence":"first","affiliation":[{"name":"Internal Medicine\/Infectious Diseases Department Son LL\u00e0tzer Hospital Palma de Mallorca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mil\u00e1 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