{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:42:49Z","timestamp":1696401769402},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T00:00:00Z","timestamp":1402444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Natural Science Fundings of China","award":["30700654"],"award-info":[{"award-number":["30700654"]}]},{"name":"National Natural Science Fundings of China","award":["81273018"],"award-info":[{"award-number":["81273018"]}]},{"name":"Science Funding of Health Department, Shaanxi Province","award":["2012D58"],"award-info":[{"award-number":["2012D58"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Osteoporosis is a systemic skeletal disease, which is more prevalent in postmenopausal women. Osteoporosis likely develops beginning with genetic risk. This study explored the relationships between polymorphisms of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B gene and postmenopausal osteoporosis in a Chinese Han population. Polymerase chain reaction sequence\u2010based typing (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>) method was used for <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> typing at <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B locus in 70 patients with postmenopausal osteoporosis and 73 healthy controls in female Han population of Shaanxi Province, situated in north\u2010western China. We found that 40 <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B alleles in postmenopausal osteoporosis patients and control subjects, respectively. Furthermore, the frequency of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B* 3501 allele was significantly higher in postmenopausal osteoporosis patients than in the control group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.033), and the relative risk was 7.632 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.927\u201362.850). Our results suggest that <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B* 3501 was likely an important risk factor for postmenopausal osteoporosis. As different populations have different <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> polymorphisms, further investigation of the relationship of various <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genes and osteoporosis with larger sample size is still necessary in the future.<\/jats:p>","DOI":"10.1111\/iji.12130","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T10:33:07Z","timestamp":1402482787000},"page":"324-329","source":"Crossref","is-referenced-by-count":3,"title":["Associations between polymorphisms of HLA\u2010B gene and postmenopausal osteoporosis in Chinese Han population"],"prefix":"10.1111","volume":"41","author":[{"given":"S.\u2010m.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.\u2010x.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical School Xi'an Jiaotong University Xi'an China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases Ministry of Education Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical School Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bone.2013.12.010","article-title":"Linkage and association analyses using families identified a locus affecting an osteoporosis\u2010related trait","volume":"60","author":"Athanasiadis G.","year":"2013","journal-title":"Bone"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.54.101601.152346"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket219"},{"key":"e_1_2_6_5_1","first-page":"89","article-title":"Genetic differences between patients with rheumatoid arthritis","volume":"51","author":"Cojocaru M.","year":"2013","journal-title":"Romanian Journal of Internal Medicine"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.12272"},{"key":"e_1_2_6_7_1","first-page":"336","article-title":"The relationship between postmenopausal osteoporosis and periodontal disease","volume":"87","author":"Dodd D.Z.","year":"2013","journal-title":"Journal of Dentistry and Oral Hygiene"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2007.00833.x"},{"key":"e_1_2_6_9_1","first-page":"256","article-title":"Relationship between osteoporosis and periodontal disease: review of the literature","volume":"9","author":"Esfahanian V.","year":"2012","journal-title":"Journal of Dentistry (Tehran)."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/07448481.2011.570399"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01183.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0548-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-010-0123-y"},{"key":"e_1_2_6_14_1","first-page":"1603","article-title":"Effect of 6\u00a0months of whole body vibration on lumbar spine bone density in postmenopausal women: a randomized controlled trial","volume":"8","author":"Lai C.L.","year":"2013","journal-title":"Clinical Interventions in Aging"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31825d24cf"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2548-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0699"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-102064"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2038-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000166209"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804093381510"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.09.017"},{"key":"e_1_2_6_23_1","first-page":"1265","article-title":"Secondary osteoporosis or secondary contributors to bone loss in fracture. 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