{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:42:18Z","timestamp":1792176138600,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T00:00:00Z","timestamp":1406246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81001317"],"award-info":[{"award-number":["81001317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81172597"],"award-info":[{"award-number":["81172597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program of Science and Technology Plan of Suzhou","award":["SYS201142"],"award-info":[{"award-number":["SYS201142"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Summary<\/jats:title>Hand, foot and mouth disease (HFMD<\/jats:styled-content>) is a common childhood illness that mainly affects Asian children under the age of 5\u00a0years. Human enterovirus 71 (EV<\/jats:styled-content>71) and coxsackievirus A16 (CA<\/jats:styled-content>16) are the most common pathogens of HFMD<\/jats:styled-content>. It is imperative that the susceptible population is screened early and that the severe illness population can be identified via genetic variation detection in children. Four single\u2010nucleotide polymorphisms (SNP<\/jats:styled-content>) [2\u2032\u20105\u2032\u2010oligoadenylate synthetase1 (OAS<\/jats:styled-content>1) rs10774671, selectin P ligand (SELPLG<\/jats:styled-content>) rs2228315, scavenger receptor class B member 2 (SCARB<\/jats:styled-content>2) rs41284767 and interleukin 28B (IL<\/jats:styled-content>28B) rs12979860] were determined by Taqman assays in 333 HFMD<\/jats:styled-content> samples and 163 control samples. The rs2228315, rs41284767 and rs12979860 polymorphisms did not differ significantly between HFMD<\/jats:styled-content> patients and the controls, but the prevalence of the rs10774671 polymorphism was significantly different between the control children and children infected with CA<\/jats:styled-content>16 (GG<\/jats:styled-content> genotype vs. AA<\/jats:styled-content>\u00a0+\u00a0AG<\/jats:styled-content> genotype, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). Children with the GG<\/jats:styled-content> genotype were more susceptible to CA<\/jats:styled-content>16\u2010type HFMD<\/jats:styled-content>. Furthermore, the rs10774671 genotype distribution was clearly different between children with severe HFMD<\/jats:styled-content> and those with mild HFMD<\/jats:styled-content> [P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05, OR<\/jats:styled-content> 0.240, 95% CI<\/jats:styled-content> (0.071\u20130.809)]. HFMD<\/jats:styled-content> children with the AA<\/jats:styled-content>+AG<\/jats:styled-content> genotype were more likely to progress to encephalitis than were those with the GG<\/jats:styled-content> genotype. Plasma \u03b3<\/jats:italic>\u2010interferon (IFN<\/jats:styled-content>) expression levels among control children and the mild and severe HFMD<\/jats:styled-content> children were detected by ELISA<\/jats:styled-content>. Those with mild HFMD<\/jats:styled-content> had higher \u03b3<\/jats:italic>\u2010IFN<\/jats:styled-content> expression levels compared with those with severe HFMD<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). In addition, there is a significant correlation between \u03b3<\/jats:italic>\u2010IFN<\/jats:styled-content> levels and OAS<\/jats:styled-content>1 rs10774671 SNP<\/jats:styled-content>, as analysed by linear correlation assay. The GG<\/jats:styled-content> genotype correlated with higher \u03b3<\/jats:italic>\u2010IFN<\/jats:styled-content> levels (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). In short, the OAS<\/jats:styled-content>1 rs10774671 SNP GG<\/jats:styled-content> genotype contributed to CA<\/jats:styled-content>16 susceptibility and was associated with the development of mild HFMD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/iji.12134","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T06:35:01Z","timestamp":1406270101000},"page":"384-392","source":"Crossref","is-referenced-by-count":21,"title":["Association analysis of polymorphisms in OAS<\/scp>1 with susceptibility and severity of hand, foot and mouth disease"],"prefix":"10.1111","volume":"41","author":[{"given":"Y.","family":"Cai","sequence":"first","affiliation":[{"name":"Soochow University Affiliated Children's Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Soochow University Affiliated Children's Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chu","sequence":"additional","affiliation":[{"name":"Soochow University Affiliated Children's Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Ji","sequence":"additional","affiliation":[{"name":"Soochow University Affiliated Children's Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ding","sequence":"additional","affiliation":[{"name":"Soochow University Affiliated Children's Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xu","sequence":"additional","affiliation":[{"name":"Soochow University Affiliated Children's Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Ji","sequence":"additional","affiliation":[{"name":"Soochow University Affiliated Children's Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"You","sequence":"additional","affiliation":[{"name":"Soochow University Affiliated Children's Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Soochow University Affiliated Children's Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(99)00019-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/314032"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb02478.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis446"},{"key":"e_1_2_7_6_1","unstructured":"HFMD clinical expert group of Chinese Ministry of health. (2010)Guidelines for the diagnosis and treatment of\u00a0hand foot and mouth disease. http:\/\/www.moh.gov.cn\/mohyzs\/s3586\/201004\/46884.shtml [Accessed on 29 June 2014]."},{"key":"e_1_2_7_7_1","unstructured":"HFMD clinical expert group of Chinese Ministry of health. 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