{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:05Z","timestamp":1787014325738,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Excellent Young Scientist Foundation of Shandong Province","award":["2006BS03018"],"award-info":[{"award-number":["2006BS03018"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30801025"],"award-info":[{"award-number":["30801025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shandong Province medicine health development plan","award":["2013WS0120"],"award-info":[{"award-number":["2013WS0120"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Summary<\/jats:title>\n \n Recent advances have highlighted a major genetic contribution to the pathogenesis of rheumatoid arthritis (\n RA<\/jats:styled-content>\n ).The aim of this study was to investigate whether polymorphisms of\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:italic>\n (rs1800630, rs1800629) and\n TNFR<\/jats:styled-content>\n 1 (rs767455) were associated with susceptibility to and clinical outcome of\n RA<\/jats:styled-content>\n in Chinese Han population. The target gene polymorphisms were genotyped in 256 patients with\n RA<\/jats:styled-content>\n and 331 healthy controls using a high resolution melting (\n HRM<\/jats:styled-content>\n ) method.\n ESR<\/jats:styled-content>\n ,\n CRP<\/jats:styled-content>\n ,\n RF<\/jats:styled-content>\n anti\u2010\n CCP<\/jats:styled-content>\n and anti\u2010\n GPI<\/jats:styled-content>\n level were also assayed and compared in genotypes of each polymorphism. Significant difference was observed in the genotype distributions and allele frequencies of\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:italic>\n rs1800629 (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.001,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001, respectively) between patients with\n RA<\/jats:styled-content>\n and controls. There is no evidence to suggest an association between genotypes of the 3\n SNP<\/jats:styled-content>\n s according to age, gender, disease duration,\n DAS<\/jats:styled-content>\n 28 and serum level of autoantibodies. This study identifies a potentially important role for\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:italic>\n rs1800629 polymorphisms in the susceptibility to\n RA<\/jats:styled-content>\n .However, further studies in larger cohorts are required.\n <\/jats:p>","DOI":"10.1111\/iji.12148","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:51:01Z","timestamp":1411951861000},"page":"499-502","source":"Crossref","is-referenced-by-count":9,"title":["Polymorphisms in the\n TNF<\/scp>\n \u2010\n \u03b1<\/i>\n ,\n TNFR<\/scp>\n 1 gene and risk of rheumatoid arthritis in Chinese Han population"],"prefix":"10.1111","volume":"41","author":[{"given":"F.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rheumatology Shandong University Qilu Hospital Qingdao Shandong China"},{"name":"Department of Rheumatology Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Psycology Shandong University Qilu Hospital Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sokolove","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology Stanford University Medical Center VA Palo Alto Health Care System Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Laiwu City People's Hospital Laiwu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Shandong University Qilu Hospital Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Shandong University Qilu Hospital Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMAMD.S6941"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23244"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.01.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10463"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-36"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70201-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken374"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8346-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090707"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-1952-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1022-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-5-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2012.02.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2011.01028.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11168"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.10.052"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/32.10.903"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1049-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000703500306"}],"container-title":["International 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