{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:24:28Z","timestamp":1788870268449,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerische Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_112651"],"award-info":[{"award-number":["31003A_112651"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerische Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_127465"],"award-info":[{"award-number":["31003A_127465"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerische Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_144180"],"award-info":[{"award-number":["31003A_144180"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000782","name":"European Science Foundation","doi-asserted-by":"publisher","award":["ESF COST Action BM0803 \u00e2\u20ac\u0153HLA-NET\u00e2\u20ac\u009d"],"award-info":[{"award-number":["ESF COST Action BM0803 \u00e2\u20ac\u0153HLA-NET\u00e2\u20ac\u009d"]}],"id":[{"id":"10.13039\/501100000782","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swiss State Secretariat for Education and Research","award":["C08.0131"],"award-info":[{"award-number":["C08.0131"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Recent studies have shown that under specific conditions such as high sample sizes and Hardy\u2013Weinberg equilibrium, bone marrow donor registry data can be used to describe\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    molecular variation across a specific geographic area, thus providing excellent data sets to infer human migrations history. The province of Quebec is known to have experienced a complex history of settlement, characterized by multiple migrations and demographic changes. We thus analysed the data of more than 13\u00a0000 unrelated individuals acting as volunteer bone marrow donors who were molecularly typed for\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    \u2010A, B and\n                    <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>\n                    1 polymorphisms in the H\u00e9ma\u2010Quebec registry.\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    allelic and haplotypic frequencies were estimated and compared among regions. The results indicate that, despite an overall low genetic diversity in Quebec, genetic variation is correlated with geography, compatible with isolation\u2010by\u2010distance across the province. However, some localities also harbour contrasting genetic profiles, that is a highly diversified genetic pool in the two main urban centres (Montr\u00e9al and Laval) and a more pronounced genetic divergence of two specific regions characterized by a peculiar peopling history (Saguenay\u2010Lac\u2010St\u2010Jean and Gasp\u00e9sie\u2010\u00celes\u2010De\u2010La\u2010Madeleine). In agreement with other independent molecular markers, the observations based on\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    data thus account for the main demographic mechanisms that shaped the genetic structure of the present day Quebecer population. In addition, the detailed analysis of the H\u00e9ma\u2010Quebec registry provides key genetic information on which an efficient bone marrow transplantation recruitment strategy can be settled.\n                  <\/jats:p>","DOI":"10.1111\/iji.12177","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T23:52:56Z","timestamp":1422661976000},"page":"69-77","source":"Crossref","is-referenced-by-count":9,"title":["<scp>HLA<\/scp>\n                    \u2010A, B and\n                    <scp>DRB<\/scp>\n                    1 genetic heterogeneity in\n                    <scp>Q<\/scp>\n                    uebec"],"prefix":"10.1111","volume":"42","author":[{"given":"S.","family":"Buhler","sequence":"first","affiliation":[{"name":"Laboratory of Anthropology, Genetics and Peopling history (AGP lab) Department of Genetics and Evolution \u2013 Anthropology Unit University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Laboratory of Anthropology, Genetics and Peopling history (AGP lab) Department of Genetics and Evolution \u2013 Anthropology Unit University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sanchez\u2010Mazas","sequence":"additional","affiliation":[{"name":"Laboratory of Anthropology, Genetics and Peopling history (AGP lab) Department of Genetics and Evolution \u2013 Anthropology Unit University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Richard","sequence":"additional","affiliation":[{"name":"Laboratoire de r\u00e9f\u00e9rence et cellules souches H\u00e9ma\u2010Qu\u00e9bec Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470114754"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.09.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.21424"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.88.9.1303"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014643"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041400"},{"key":"e_1_2_6_8_1","first-page":"364","article-title":"The HLA genetic relationship between a well\u2010defined Slovenian population sample and the national haematopoietic stem cell donor registry","volume":"81","author":"Buhler S.","year":"2013","journal-title":"Tissue Antigens"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01539.x"},{"key":"e_1_2_6_10_1","volume-title":"The First French Canadians. Pioneers in the St. Lawrence Valley","author":"Charbonneau H.","year":"1993"},{"key":"e_1_2_6_11_1","first-page":"99","volume-title":"A Population History of North America","author":"Charbonneau H.","year":"2000"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-10-237"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004561"},{"key":"e_1_2_6_14_1","volume-title":"Histoire de la Gasp\u00e9sie","author":"Desjardins M.","year":"1999"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2006.03067.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2003.tb00580.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330980102"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01183.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2008.00865.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000132327.40702.97"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02289694"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20072311997"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2005.00497.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086758"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199508270-00013"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.7182\/prtr.17.3.np2316450n345u67"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01151.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3378\/027.082.0407"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.1998.tb01520.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.2001.6510001.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.391"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.21012"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1212880"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2010.00617.x"},{"key":"e_1_2_6_35_1","unstructured":"Nunes J.M.(2014)Using uniformat and gene[rate] to analyse data with ambiguities in population genetics.http:\/\/dx.doi.org\/10.6084\/m9.figshare.984299[Accessed on 5 April 2014]."},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3378\/027.083.0307"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12356"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12276"},{"key":"e_1_2_6_39_1","volume-title":"Les Saguenayens. Introduction \u00e0 L'histoire des Populations du Saguenay","author":"Pouyez C.","year":"1983"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00831894"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.04.050"},{"key":"e_1_2_6_42_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R\u2010core\u2010team","year":"2013"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb02277.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq998"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0945-x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.00802.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03438.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0312"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360855"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.08.006"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01520.x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073835"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12478"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2008.05.001"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:05:54Z","timestamp":1696345554000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/iji.12177"],"URL":"https:\/\/doi.org\/10.1111\/iji.12177","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}