{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:30:01Z","timestamp":1789875001384,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Department of Science and Technology of Shaanxi Province","award":["2013FWPT-06"],"award-info":[{"award-number":["2013FWPT-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is an intractable, chronic inflammatory disorder, and its pathogenesis is still largely unknown. Some literatures supported that genes involved in both oxidative stress and prostaglandin metabolism play an important role in the process of inflammation. To explore their association with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, we investigated four single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) from myeloperoxidase (<jats:italic><jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content><\/jats:italic>) and cyclooxygenase (<jats:italic><jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content><\/jats:italic>) genes in 475 Chinese individuals (242 case and 233 controls) by <jats:sc>MassArray<\/jats:sc>. Although the genotype distributions had no significant differences between the patients and controls, we found that in different gender, rs2243828 from <jats:italic><jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content><\/jats:italic> displayed the statistically significant variance genotype frequencies between patients and controls (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018 in females, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.035 in males). Moreover, for the major allele recessive model, this <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> also showed a significant difference between case and control groups in males (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.015). In this study, we first observed significant association with <jats:italic><jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content><\/jats:italic> polymorphism and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> risk in different gender groups in Chinese, suggesting <jats:italic><jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content><\/jats:italic> polymorphism is a gender\u2010specific risk factor of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> probably by influencing sex hormone\u2010sensitive elements to regulate inflammatory gene expression networks, and we further revealed that oxidative stress was actually involved in the pathogenesis of this disease. Moreover, these findings inspire us some constructive solutions to the treatment of this disease.<\/jats:p>","DOI":"10.1111\/iji.12193","type":"journal-article","created":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T16:05:34Z","timestamp":1427731534000},"page":"161-167","source":"Crossref","is-referenced-by-count":13,"title":["Association of single nucleotide polymorphisms in <scp><i>MPO<\/i><\/scp> and <scp><i>COX<\/i><\/scp> genes with oral lichen planus"],"prefix":"10.1111","volume":"42","author":[{"given":"D.","family":"Wu","sequence":"first","affiliation":[{"name":"Center for DNA Typing Department of Biochemistry and Molecular Biology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for DNA Typing Department of Biochemistry and Molecular Biology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dong","sequence":"additional","affiliation":[{"name":"Hematology Department Xianyang Rainbow Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Liu","sequence":"additional","affiliation":[{"name":"Periodontal Mucosal Department School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for DNA Typing Department of Biochemistry and Molecular Biology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"He","sequence":"additional","affiliation":[{"name":"Center for DNA Typing Department of Biochemistry and Molecular Biology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry &amp; Endodontics School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for DNA Typing Department of Biochemistry and Molecular Biology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for DNA Typing Department of Biochemistry and Molecular Biology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,30]]},"reference":[{"issue":"25","key":"e_1_2_8_2_1","first-page":"e1","article-title":"Oral 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